ReviewInternational journal of geriatric psychiatry2014
The effects of aging on insight into illness in schizophrenia: a review.
Review in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Efficacy of Transcranial Direct Current Stimulation to Improve Insight in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Schizophrenia bulletin · 2022Pooled it
- Poor Insight in Schizophrenia Patients in China: a Meta-Analysis of Observational Studies.The Psychiatric quarterly · 2020Pooled it
- Impaired Awareness of Problem and Pathological Gambling: A Review.Journal of gambling studies · 2020Pooled it
- BASIS: The blood pressure awareness and insight scale.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- Treatment effect with paliperidone palmitate compared with oral antipsychotics in patients with recent-onset versus more chronic schizophrenia and a history of criminal justice system involvement.Early intervention in psychiatry · 2018Trial
- Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders.Psychiatry research · 2017Trial
- Validation of the Gambling Problem Recognition Scale.Journal of gambling studies · 2026Article
- Brain imaging data and summary data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia.Frontiers in psychiatry · 2025Article
- Real-world predictors of relapse in patients with schizophrenia and schizoaffective disorder in a large health system.Schizophrenia (Heidelberg, Germany) · 2024Review
- How can we improve the care of patients with schizophrenia in the real-world? A population-based cohort study of 456,003 patients.Molecular psychiatry · 2023Article
- Role of Clinical Insight at First Month in Predicting Relapse at the Year in First Episode of Psychosis (FEP) Patients.Journal of clinical medicine · 2023Article
- Commentary: "Exploring the "Insight Paradox" in Treatment Resistant Schizophrenia: Correlations Between Dimensions of Insight and Depressive Symptoms in Patients Receiving Clozapine".Alpha psychiatry · 2023Article
- Exploring the "Insight Paradox" in Treatment-Resistant Schizophrenia: Correlations Between Dimensions of Insight and Depressive Symptoms in Patients Receiving Clozapine.Alpha psychiatry · 2023Article
- Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- National trends in metabolic risk of psychiatric inpatients in the United States during the atypical antipsychotic era.Schizophrenia research · 2022Article
- A Measure to Assess Illness Awareness in Problem Gambling: Gambling Awareness and Insight Scale (GAS).Journal of gambling studies · 2022Article
- A Measure of Illness Awareness in Individuals With Nicotine Dependence-Nicotine Use Awareness and Insight Scale.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [Neuropsychiatric disease and treatment · 2021Article
- Impaired illness awareness in schizophrenia and posterior corpus callosal white matter tract integrity.NPJ schizophrenia · 2019Article
- The Multiple Dimensions of Insight in Schizophrenia-Spectrum Disorders.Schizophrenia bulletin · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesImpaired insight into illness is a prevalent feature of schizophrenia, which negatively influences treatment adherence and clinical outcomes. Little is known about the effects of aging on insight impairment. We aimed to review the available research literature on the effects of aging on insight into illness in schizophrenia, in relation to positive, negative, and cognitive symptoms. Ultimately, we propose a trajectory of insight in schizophrenia across the lifespan.
methodA systematic Medline® literature search was conducted, searching for English language studies describing the relationship of insight into illness in schizophrenia with aging.
resultsWe identified 62 studies. Insight impairment is associated with illness severity, premorbid intellectual function (i.e. IQ), executive function, and memory. Insight impairment improves modestly during midlife, worsening again in late life. It tends to fluctuate with each episode of psychosis, likely in relation to worsening positive symptoms that improve with antipsychotic treatment. The relationship between insight impairment and cognitive dysfunction appears to attenuate with age, while the relationship with lower premorbid intellectual function is preserved. The association between impaired insight and negative symptoms is unclear.
conclusionsThe available literature suggests that the course of insight impairment follows a U-shaped curve, where insight impairment is severe during the first episode of psychosis, modestly improves over midlife, and declines again in late life. Future studies are required to investigate the trajectory of insight into illness and its core domains across the lifespan from prodromal phase to late life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.