Evidence map›Paper›PMID 25055077›Full record

ArticleThe Journal of cardiovascular nursing

Cognitive Function in Heart Failure Is Associated With Nonsomatic Symptoms of Depression But Not Somatic Symptoms.

Misty A W Hawkins, Mary A Dolansky, Julie T Schaefer, Michael J Fulcher, John Gunstad, Joseph D Redle, Richard Josephson, Joel W Hughes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cardiovascular nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Misty A W HawkinsMisty A.W. Hawkins, PhD Research Fellow, Department of Psychology, Kent State University, Ohio. Mary A. Dolansky, PhD, RN Associate Professor, School of Nursing, Case Western Reserve University, Cleveland, Ohio. Julie T. Schaefer, MS, RD PhD Candidate, College of Public Health, Kent State University, Ohio. Michael J. Fulcher, BA Project Coordinator, Department of Psychiatry, Summa Health System, Akron City Hospital, Ohio. John Gunstad, PhDAssociate Professor, Department of Psychology, Kent State University, Ohio. Joseph D. Redle, MD Cardiologist, Cardiovascular Institute, Summa Health System, Akron City Hospital, Ohio. Richard Josephson, MS, MD Professor, School of Medicine, Case Western Reserve University, and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, Ohio. Joel W. Hughes, PhD Associate Professor, Department of Psychology, Kent State University, and Department of Psychiatry, Summa Health System, Akron City Hospital, Ohio.
Mary A Dolansky
Julie T Schaefer
Michael J Fulcher
John Gunstad
Joseph D Redle
Richard Josephson
Joel W Hughes
Summa Health System · US

Funding

Cognitive Impairment and Self-management in Adults with Heart FailureR01HL096710 · NHLBI · KENT STATE UNIVERSITY · PI DOLANSKY, MARY, HUGHES, JOEL W · 2010 to 2013
$2.7M
NHLBI NIH HHS R01 HL096710NHLBI NIH HHS (R01 HL096710-01A1
6 · The paper itself

Abstract

backgroundPatients with heart failure (HF) have high rates of cognitive impairment and depressive symptoms. Depressive symptoms have been associated with greater cognitive impairments in HF; however, it is not known whether particular clusters of depressive symptoms are more detrimental to cognition than others.

objectiveThe aim of this study was to identify whether somatic and/or nonsomatic depressive symptom clusters were associated with cognitive function in persons with HF.

methodsParticipants were 326 HF patients (40.5% women, 26.7% non-white race-ethnicity, aged 68.6 ± 9.7 years). Depressive symptoms were measured using a depression questionnaire commonly used in medical populations: the Patient Health Questionnaire-9. Somatic and nonsomatic subscale scores were created using previous factor analytic results. A neuropsychological battery tested attention, executive function, and memory. Composites were created using averages of age-adjusted scaled scores. Regressions adjusting for demographic and clinical factors were conducted.

resultsRegressions revealed that Patient Health Questionnaire-9 total was associated with attention (β = -.14, P = .008) and executive function (β = -.17, P = .001). When analyzed separately, the nonsomatic subscale, but not the somatic symptoms subscale (P values ≥ .092), was associated with attention scores (β = -.15, P = .004) and memory (β = -.11, P = .044). Both nonsomatic (β = -.18, P < .001) and somatic (β = -.11, P = .048) symptoms were related to executive function. When included together, only the nonsomatic symptom cluster was associated with attention (β = -.15, P = .020) and executive function (β = -.19, P = .003).

conclusionsGreater overall depressive symptom severity was associated with poorer performance on multiple cognitive domains, an effect driven primarily by the nonsomatic symptoms of depression. CLINICAL IMPLICATIONS: These findings suggest that screening explicitly for nonsomatic depressive symptoms may be warranted and that the mechanisms underlying the depression-cognitive function relationship in HF are not solely related to sleep or appetite disturbance. Thus, interventions that target patients' somatic symptoms only (eg, poor appetite or fatigue) may not yield maximum cognitive benefit compared with a comprehensive treatment that targets depressed mood, anhedonia, and other nonsomatic symptoms.

Indexed as

AgedAttentionCluster AnalysisCognition DisordersCohort StudiesDepressionExecutive FunctionFemaleHeart FailureHumansMaleMiddle AgedNeuropsychological TestsRisk FactorsSocioeconomic Factors

Identifiers

PMID25055077
PMCPMC4303562
OpenAlexW2333810700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.