ArticleNature chemistry2014
Controlling epithelial sodium channels with light using photoswitchable amilorides.
Article in Nature chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Mechanistic Insight into Para-Substituent Control of Thermal Half-Lives in Arylazopyrazole Photoswitches.Angewandte Chemie (International ed. in English) · 2025Article
- Photoisomerization of Azobenzene-Extended Charybdotoxin for the Optical Control of KAngewandte Chemie (International ed. in English) · 2025Article
- Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis.Angewandte Chemie (International ed. in English) · 2025Article
- Synthetic Biology Meets CaCells · 2024Review
- First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent.Cells · 2023Article
- TRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel.Journal of the American Chemical Society · 2020Article
- Optical Manipulation of F-Actin with Photoswitchable Small Molecules.Journal of the American Chemical Society · 2020Article
- Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Phenotyping of RareCells · 2020Article
- A photochromic upconversion nanoarchitecture: towards activatable bioimaging and dual NIR light-programmed singlet oxygen generation.Chemical science · 2019Article
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Segmental differences in ion transport in rat cecum.Pflugers Archiv : European journal of physiology · 2019Article
- Article
- Incorporation of the δ-subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs inThe Journal of biological chemistry · 2018Article
- A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.Scientific reports · 2017Article
- Redox Control over Acyl Hydrazone Photoswitches.Journal of the American Chemical Society · 2017Article
- Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist.Chemical science · 2017Article
- Light-controlled modulation of gene expression by chemical optoepigenetic probes.Nature chemical biology · 2016Article
- Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO).Chemical science · 2016Article
- Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro.Pflugers Archiv : European journal of physiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amiloride is a widely used diuretic that blocks epithelial sodium channels (ENaCs). These heterotrimeric transmembrane proteins, assembled from β, γ and α or δ subunits, effectively control water transport across epithelia and sodium influx into non-epithelial cells. The functional role of δβγENaC in various organs, including the human brain, is still poorly understood and no pharmacological tools are available for the functional differentiation between α- and δ-containing ENaCs. Here we report several photoswitchable versions of amiloride. One compound, termed PA1, enables the optical control of ENaC channels, in particular the δβγ isoform, by switching between blue and green light, or by turning on and off blue light. PA1 was used to modify functionally δβγENaC in amphibian and mammalian cells. We also show that PA1 can be used to differentiate between δβγENaC and αβγENaC in a model for the human lung epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.