ArticlePloS one2014
Sequence, structural and expression divergence of duplicate genes in the bovine genome.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Evolution of CCR1 and CCR1L1 reveals complex duplication scenarios in Muroids and Ruminants.Immunogenetics · 2026Article
- Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary diversification of ancestral genes across vertebrates and insects.Genome biology · 2025Article
- BuffExDb: web-based tissue-specific gene expression resource for breeding and conservation programmes in Bubalus bubalis.Database : the journal of biological databases and curation · 2025Article
- Article
- Identification of genomic regions affecting nitrogen excretion intensity in Brown Swiss dairy cows.Animal biotechnology · 2024Article
- Article
- Article
- Landscape of adenosine-to-inosine RNA recoding across human tissues.Nature communications · 2022Article
- Article
- TheFrontiers in molecular neuroscience · 2021Article
- The differential expression patterns of paralogs in response to stresses indicate expression and sequence divergences.BMC plant biology · 2020Article
- Intron and gene size expansion during nervous system evolution.BMC genomics · 2020Article
- Genome wide identification and comparative analysis of glutathione transferases (GST) family genes in Brassica napus.Scientific reports · 2019Article
- Computational identification of tissue-specific transcription factor cooperation in ten cattle tissues.PloS one · 2019Article
- Variation of gene expression in plants is influenced by gene architecture and structural properties of promoters.PloS one · 2019Article
- The evolution of duplicate gene expression in mammalian organs.Genome research · 2017Article
- Expression Divergence of Duplicate Genes in the Protein Kinase Superfamily in Pacific Oyster.Evolutionary bioinformatics online · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplication is a widespread phenomenon in genome evolution, and it has been proposed to serve as an engine of evolutionary innovation. In the present study, we performed the first comprehensive analysis of duplicate genes in the bovine genome. A total of 3131 putative duplicated gene pairs were identified, including 712 cattle-specific duplicate gene pairs unevenly distributed across the genome, which are significantly enriched for specific biological functions including immunity, growth, digestion, reproduction, embryonic development, inflammatory response, and defense response to bacterium. Around 97.1% (87.8%) of (cattle-specific) duplicate gene pairs were found to have distinct exon-intron structures. Analysis of gene expression by RNA-Seq and sequence divergence (synonymous or non-synonymous) revealed that expression divergence is correlated with sequence divergence, as has been previously observed in other species. This analysis also led to the identification of a subset of cattle-specific duplicate gene pairs exhibiting very high expression divergence. Interestingly, further investigation revealed a significant relationship between structural and expression divergence while controlling for the effect of synonymous sequence divergence. Together these results provide further insight into duplicate gene sequence and expression divergence in cattle, and their potential contributions to phenotypic divergence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.