Evidence map›Paper›PMID 25054646›Full record

ArticleAIDS care2015

Combined prevention for persons who inject drugs in the HIV epidemic in a transitional country: the case of Tallinn, Estonia.

Anneli Uusküla, Don C Des Jarlais, Mait Raag, Steven D Pinkerton, Jonathan Feelemyer

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Anneli Uuskülaa Department of Public Health , University of Tartu , Tartu , Estonia.
Don C Des Jarlais
Mait Raag
Steven D Pinkerton
Jonathan Feelemyer
Mount Sinai Beth Israel · USUniversity of Tartu · EEMedical College of Wisconsin · US

Funding

Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI John Edward Pachankis · 2001 to 2026
$48.5M
Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
QUANTITATIVE COREP30MH052776 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI MCAULIFFE, TIMOTHY L · 1994 to 2018
$33.2M
Multiple HIV Prevention Packages for IDUs in EstoniaR01AI083035 · NIAID · BETH ISRAEL MEDICAL CTR (NEW YORK) · PI DES JARLAIS, DON C · 2009 to 2012
$2.5M
NIAID NIH HHS R01 AI083035NIAID NIH HHS R01AI083035NIDA NIH HHS P30 DA011041NIMH NIH HHS P30 MH052776NIMH NIH HHS P30MH052776NIMH NIH HHS P30 MH062294
6 · The paper itself

Abstract

The study was undertaken to assess the potential effectiveness of combined HIV prevention on the very high seroprevalence epidemic among persons who inject drugs (PWID) in Tallinn, Estonia, a transitional country. Data from community-based cross-sectional (respondent-driven sampling) surveys of PWID in 2005, 2007, 2009, and 2011 were used together with mathematical modeling of injection-associated HIV acquisition to estimate changes in injection-related HIV incidence during these periods. Utilization of one, two, or three of the interventions available in the community (needle and syringes exchange program, antiretroviral treatment [ART], HIV testing, opioid substitution treatment) was reported by 42.5%, 30.5%, and 11.5% of HIV+ and 34.7%, 36.4%, and 5.7% of HIV- PWIDs, respectively, in 2011. The modeling results suggest that the combination of needle/syringe programs and provision of ART to PWID in Tallinn substantially reduced the incidence of HIV infection in this population, from an estimated 20.7/100 person-years in 2005 to 7.5/100 person-years in 2011. In conclusion, combined prevention targeting HIV acquisition and transmission-related risks among PWID in Tallinn has paralleled the downturn of the HIV epidemic in this population.

Indexed as

Substance Abuse, IntravenousAnti-HIV AgentsEstoniaHIV InfectionsHumansNeedle-Exchange ProgramsPreventive Health ServicesAnti-HIV Agentsantiretroviral treatmentHIVopioid substitution treatmentpersons who inject drugsprevention

Identifiers

PMID25054646
PMCPMC4221426
OpenAlexW1988324610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.