Evidence map›Paper›PMID 25054348›Full record

ArticlePloS one2014

MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.

Shashank Gupta, Pradeep Kumar Bhaskar, Ritu Bhardwaj, Abhishek Chandra, Vidya Nair Chaudhry, Prashaant Chaudhry, Akhtar Ali, Ashim Mukherjee, Mousumi Mutsuddi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shashank GuptaDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India.
Pradeep Kumar BhaskarDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India.
Ritu BhardwajDepartment of Zoology, Banaras Hindu University, Varanasi, India.
Abhishek ChandraDepartment of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Vidya Nair ChaudhryR. K. Netralaya Eye Hospital & Research Centre, Varanasi, India.
Prashaant ChaudhryR. K. Netralaya Eye Hospital & Research Centre, Varanasi, India.
Akhtar AliCentre for Genetic Disorders, Banaras Hindu University, Varanasi, India.
Ashim MukherjeeDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India.
Mousumi MutsuddiDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India.
Banaras Hindu University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal ganglion cells (RGC), which is a characteristic feature of glaucoma. However, association of MTHFR C677T with glaucoma has been controversial because of inconsistent results across association studies. Association between MTHFR C677T and glaucoma has not been reported in Indian population. Therefore, with a focus on neurodegenerative death of RGC in glaucoma, the current study aimed to investigate association of MTHFR C677T with Primary Open Angle Glaucoma (POAG) and Primary Angle Closure Glaucoma (PACG) in a North Indian population. A total of 404 participants (231 patients and 173 controls) were included in this study. Genotyping was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. A few random samples were also tested by direct sequencing. Genotypic and allelic distributions of the POAG and PACG cohorts were compared to that of controls by chi-square test and odds ratios were reported with 95% confidence intervals. Genotypic and allelic distributions between POAG cases and controls were significantly different (p = 0.03 and p = 0.01 respectively). Unlike POAG, we did not find significant difference in the genotypic and allelic distributions of C677T between PACG cases and controls (p>0.05). We also observed a higher proportion of TT associated POAG in females than that in males. However, this is a preliminary indication of gender specific risk of C677T that needs to be replicated in a larger cohort of males and females. The present investigation on MTHFR C677T and glaucoma reveals that the TT genotype and T allele of this polymorphism are significant risk factors for POAG but not for PACG in North Indian population. Ours is the first report demonstrating association of MTHFR C677T with POAG but not PACG in individuals from North India.

Indexed as

Polymorphism, Single NucleotideAgedAllelesCase-Control StudiesCohort StudiesFemaleGenetic Predisposition to DiseaseGenotypeGlaucoma, Angle-ClosureGlaucoma, Open-AngleHumansIndiaMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedMethylenetetrahydrofolate Reductase (NADPH2)

Identifiers

PMID25054348
PMCPMC4108368
OpenAlexW2154072759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.