ArticleThe Angle orthodontist2015
Bone marrow mesenchymal stem cells enhance bone formation in orthodontically expanded maxillae in rats.
Article in The Angle orthodontist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Mesenchymal stem cells derived from gingiva normoxic or hypoxic-preconditioning allogenous transplantation affect orthodontic tooth movement in vivo.Journal of dental sciences · 2026Article
- Article
- Ameliorating orthodontic relapse using laser bio-stimulation and mesenchymal stem cells in rats.Journal, genetic engineering & biotechnology · 2024Article
- The Condylar Effects of Mesenchymal Stem Cells, Low-Level Laser Therapy and Grape Seed Extract on Functional Mandibular Advancement of the Rat Mandible.Turkish journal of orthodontics · 2023Article
- Suture Cells in a Mechanical Stretching Niche: Critical Contributors to Trans-sutural Distraction Osteogenesis.Calcified tissue international · 2022Review
- Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats.Drug design, development and therapy · 2021Article
- Effect of mesenchymal stem cells injection and low-level laser therapy on bone formation after rapid maxillary expansion: an animal study.American journal of stem cells · 2020Article
- Stem Cells and Their Application in Dentistry: A Review.Journal of pharmacy & bioallied sciences · 2019Review
- Applications of stem cells in orthodontics and dentofacial orthopedics: Current trends and future perspectives.World journal of stem cells · 2018Review
- A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study.Turkish journal of biology = Turk biyoloji dergisi · 2018Article
- Osteogenic potential of gingival stromal progenitor cells cultured in platelet rich fibrin is predicted by core-binding factor subunit-α1/Sox9 expression ratio (F1000Research · 2018Article
- Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen-nanodiamond hydrogel.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The effect of different concentrations of topical ozone administration on bone formation in orthopedically expanded suture in rats.European journal of orthodontics · 2016Article
- Histological Evaluation of Periodontal Ligament in Response to Orthodontic Mechanical Stress in Mice.International journal of medical sciences · 2015Article
- Bone alkaline phosphatase and osteocalcin expression of rat's Gingival mesenchymal stem cells cultured in platelet-rich fibrin for bone remodeling (European journal of dentistryArticle
Corrections and comments
- Commented on by
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- Erratum issuedErratum.2015
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo transplant bone marrow-derived mesenchymal stem cells (MSCs) into the interpremaxillary suture after rapid maxillary expansion with the aim of increasing new bone formation in the suture. MATERIALS AND
methodsNineteen male Wistar rats were divided into two groups (control, n = 9; experimental, n = 10). Both groups were subjected to expansion for 5 days, and 50 cN of force was applied to the maxillary incisors with a helical spring. Pkh67(+) (green fluorescent dye)-labeled MSCs were applied to the interpremaxillary suture after force application into the interpremaxillary suture of rats. Bone formation in the sutural area was histomorphometrically evaluated, including the amount of new bone formation (µm(2)), number of osteoblasts, number of osteoclasts, and number of vessels. Mann-Whitney U-test was used for statistical evaluation at the P < .05 level.
resultsAfter 10 days of retention, Pkh67(+) can be detected in suture mostly in the injection site under fluorescence microscope. Histomorphometric analysis revealed that a single local injection of MSCs into the midpalatal suture increased the new bone formation in the suture by increasing the number of osteoblasts and new vessel formation, compared with controls injected with phosphate-buffered saline.
conclusionsThis preclinical study might provide foundations for the underlying potential clinical use of MSCs after maxillary expansion. Given the fact that MSCs are currently in use in clinical trials, this approach might be a feasible treatment strategy to accelerate new bone tissue formation in midpalatal suture and to shorten the treatment period for patients undergoing maxillary expansion reinforcement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.