ReviewPreventive nutrition and food science2014
Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits.
Review in Preventive nutrition and food science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 137 citations in OpenAlex.
- Blood Microbiota Profile Is Associated with the Responsiveness of Postprandial Lipemia toNutrients · 2023Trial
- Effect of Jiegeng () on Jingjie () "" into the lungs based on pharmacokinetics.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Role of Saponins fromMolecules (Basel, Switzerland) · 2025Article
- Distribution Patterns ofEcology and evolution · 2025Article
- Optimization of Intercropping Modes inPlant-environment interactions (Hoboken, N.J.) · 2025Article
- Review
- Immunostimulatory Activity of a Mixture ofInternational journal of molecular sciences · 2024Article
- Ethnopharmacology, phytochemistry, pharmacology and product application ofChinese herbal medicines · 2024Review
- Biotransformation and pharmacological activities of platycosides fromChinese herbal medicines · 2024Review
- Revealing Molecular Mechanisms of the Bioactive Saponins from Edible Root ofPlants (Basel, Switzerland) · 2024Article
- Article
- Article
- Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in drought stress ofFrontiers in plant science · 2024Article
- Bei Mu Gua Lou San facilitates mucus expectoration by increasing surface area and hydration levels of airway mucus in an air-liquid-interface cell culture model of the respiratory epithelium.BMC complementary medicine and therapies · 2023Article
- Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells.Clinical & experimental metastasis · 2023Article
- Therapeutic Candidates for Alzheimer's Disease: Saponins.International journal of molecular sciences · 2023Review
- Balloon Flower Root-Derived Extracellular Vesicles: In Vitro Assessment of Anti-Inflammatory, Proliferative, and Antioxidant Effects for Chronic Wound Healing.Antioxidants (Basel, Switzerland) · 2023Article
- Immune-enhancing effect of hydrolyzed and fermentedNutrition research and practice · 2023Article
- Chromosome-Scale Genome Assembly and Triterpenoid Saponin Biosynthesis in Korean Bellflower (International journal of molecular sciences · 2023Article
- Biotransformation of Platycosides, Saponins from Balloon Flower Root, into Bioactive Deglycosylated Platycosides.Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracts and pure saponins from the roots of Platycodon grandiflorum (PG) are reported to have a wide range of health benefits. Platycosides (saponins) from the roots of PG are characterized by a structure containing a triterpenoid aglycone and two sugar chains. Saponins are of commercial significance, and their applications are increasing with increasing evidence of their health benefits. The biological effects of saponins include cytotoxic effects against cancer cells, neuroprotective activity, antiviral activity, and cholesterol lowering effects. Saponins with commercial value range from crude plant extracts, which can be used for their foaming properties, to high purity saponins such as platycodin D, which can be used for its health applications (e.g., as a vaccine adjuvant). This review reveals that platycosides have many health benefits and have the potential to be used as a remedy against many of the major health hazards (e.g., cancer, obesity, alzheimer's) faced by populations around the world. Methods of platycoside purification and analysis are also covered in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.