ArticleTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2014
Storage-induced damage to red blood cell mechanical properties can be only partially reversed by rejuvenation.
Article in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Efficacy of the BioBox LAB10 for maintaining temperature and quality of packed red blood cells during in-hospital storage and transport.Transfusion medicine (Oxford, England) · 2026Article
- Red Blood Cells in Normal and Pathological States: Redox Reactions of Hemoglobin.Molecules (Basel, Switzerland) · 2026Review
- Mechanical Stimulation of Red Blood Cells Aging: Focusing on the Microfluidics Application.Micromachines · 2025Review
- Investigation on the Interaction of Dendritic Core Multi-Shell Nanoparticles with Human Red Blood Cells.Nanomaterials (Basel, Switzerland) · 2025Article
- Tired and stressed: direct holographic quasi-static stretching of aging echinocytes and discocytes in plasma using optical tweezers [Invited].Biomedical optics express · 2024Article
- Production of Feline Universal Erythrocytes with Methoxy Polyethylene Glycol.Journal of functional biomaterials · 2023Article
- The Effect of the Donor's and Recipient's Sex on Red Blood Cells Evaluated Using Transfusion Simulations.Cells · 2023Article
- Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility.Micromachines · 2022Review
- Biochemical and Biophysical Properties of Red Blood Cells in Disease.Biomolecules · 2022Article
- Industrially Compatible Transfusable iPSC-Derived RBCs: Progress, Challenges and Prospective Solutions.International journal of molecular sciences · 2021Review
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- An Insight into the Stages of Ion Leakage during Red Blood Cell Storage.International journal of molecular sciences · 2021Article
- Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform.Communications biology · 2021Article
- Dietary Selenium Deficiency Facilitated Reduced Stomatin and Phosphatidylserine Externalization, Increasing Erythrocyte Osmotic Fragility in Mice.Biological trace element research · 2021Article
- Deformability of Stored Red Blood Cells.Frontiers in physiology · 2021Review
- Red blood cell osmotic fragility in healthy loggerhead and green sea turtles.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- Effect of DMSO on the Mechanical and Structural Properties of Model and Biological Membranes.Biophysical journal · 2020Article
- Effects of rejuvenation on young and old erythrocytes of banked blood towards the end of storage period.American journal of blood research · 2020Article
- Continuous noninvasive glucose monitoring; water as a relevant marker of glucose uptake in vivo.Biophysical reviews · 2019Review
- Transition to 37°C reveals importance of NADPH in mitigating oxidative stress in stored RBCs.JCI insight · 2019Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe storage of red blood cells (RBC) is associated with impairment of their properties that can induce a circulatory risk to recipients. In a preceding study (2009), we reported that post-storage rejuvenation (RJ) of stored RBC (St-RBC) efficiently reduced the storage-induced RBC/endothelial cell interaction, while only partially reversing the level of intracellular Ca(2+), reactive oxygen species, and surface phosphatidylserine. In the present study, we examined the RJ effectiveness in repairing St-RBC mechanical properties.
methodsRBC, stored in CPDA-1 without pre-storage leukoreduction, were subjected to post-storage RJ, and the deformability, osmotic fragility (OF), and mechanical fragility (MF) of the rejuvenated St-RBC (St-RBCRj) were compared to those of untreated St-RBC and of freshly-collected RBC (F-RBC).
results5-week storage considerably increased OF and MF, and reduced the deformability of St-RBC. All alterations were only partially (40-70%) reversed by RJ, depending on the extent of the damage: the greater the damage, the lesser the relative effect of RJ.
conclusionThe findings of the present and preceding studies suggest that different St-RBC properties are differentially reversed by RJ, implying that some of the changes occur during storage and are irreversible.
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