ArticleGenome research2014
Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals.
Article in Genome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 185 papers, 2 of them syntheses that pooled it.
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Who cites it
185 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Olfactory dysfunction in aging and neurodegenerative diseases.Ageing research reviews · 2021Pooled it
- Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review.Integrative cancer therapiesPooled it
- The Origins of GPCRs.International journal of molecular sciences · 2026Review
- Decoding Smell from Receptor Structure.Research square · 2026Article
- Molecular Evidence for the Parallel Evolution of Anosmia in Multiple Odontoceti (Toothed Whales) Clades.Genes · 2026Article
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- But how does it smell? An investigation of olfactory bulb size among living and fossil primates and other euarchontoglirans.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Decoding odor responses: universal patterns and individual signatures in psychophysiology using nonlinear models.Chemical senses · 2026Article
- The olfactory bulb endocast as a proxy for mammalian olfaction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identifying Key Regulators in Odorant Receptor Trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Divergent selection, recombination variability, and noncoding introgression drive speciation and adaptation in threadfin Eleutheronema.Communications biology · 2025Article
- A Structure-Based Approach for Predicting Odor Similarity of Molecules via Docking Simulations with Human Olfactory Receptors.ACS omega · 2025Article
- Shifts in bee diet breadths are associated with gene gains and losses and positive selection across olfactory receptors.G3 (Bethesda, Md.) · 2025Article
- Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium.Development, growth & differentiation · 2025Article
- Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolution of the Nonvisual and Visual Opsin Gene Repertoire in Ray-Finned Fishes.Genome biology and evolution · 2025Article
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- An odorant receptor for a key odor constituent of ambergris.Communications biology · 2025Article
- The chordata olfactory receptor database.Protein & cell · 2025Article
125 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptors (ORs) detect odors in the environment, and OR genes constitute the largest multigene family in mammals. Numbers of OR genes vary greatly among species--reflecting the respective species' lifestyles--and this variation is caused by frequent gene gains and losses during evolution. However, whether the extent of gene gains/losses varies among individual gene lineages and what might generate such variation is unknown. To answer these questions, we used a newly developed phylogeny-based method to classify >10,000 intact OR genes from 13 placental mammal species into 781 orthologous gene groups (OGGs); we then compared the OGGs. Interestingly, African elephants had a surprisingly large repertoire (∼ 2000) of functional OR genes encoded in enlarged gene clusters. Additionally, OR gene lineages that experienced more gene duplication had weaker purifying selection, and Class II OR genes have evolved more dynamically than those in Class I. Some OGGs were highly expanded in a lineage-specific manner, while only three OGGs showed complete one-to-one orthology among the 13 species without any gene gains/losses. These three OGGs also exhibited highly conserved amino acid sequences; therefore, ORs in these OGGs may have physiologically important functions common to every placental mammal. This study provides a basis for inferring OR functions from evolutionary trajectory.
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