ArticleDevelopment (Cambridge, England)2014
Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
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- Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood-brain barrier.PLoS biology · 2025Article
- Glia as Functional Barriers and Signaling Intermediaries.Cold Spring Harbor perspectives in biology · 2024Review
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- The exit of axons and glial membrane from the developing Drosophila retina requires integrins.Molecular brain · 2022Article
- The Fly Blood-Brain Barrier Fights Against Nutritional Stress.Neuroscience insights · 2022Review
- The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries inCells · 2021Article
- Early lineage segregation of the retinal basal glia in the Drosophila eye disc.Scientific reports · 2020Article
- Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in theJournal of cell science · 2020Article
- Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology.Molecular biology of the cell · 2020Review
- Identification of key miRNAs and genes for mouse retinal development using a linear model.Molecular medicine reports · 2020Article
- Review
- An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila.Molecular brain · 2020Article
- Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina.PloS one · 2018Article
- Turtle interacts with borderless in regulating glial extension and axon ensheathment.Molecular brain · 2017Article
- dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation.PLoS genetics · 2017Article
- The effect of TIMP-1 on the cone mosaic in the retina of the rat model of retinitis pigmentosa.Investigative ophthalmology & visual science · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many aspects of glial development are regulated by extracellular signals, including those from the extracellular matrix (ECM). Signals from the ECM are received by cell surface receptors, including the integrin family. Previously, we have shown that Drosophila integrins form adhesion complexes with Integrin-linked kinase and talin in the peripheral nerve glia and have conserved roles in glial sheath formation. However, integrin function in other aspects of glial development is unclear. The Drosophila eye imaginal disc (ED) and optic stalk (OS) complex is an excellent model with which to study glial migration, differentiation and glia-neuron interactions. We studied the roles of the integrin complexes in these glial developmental processes during OS/eye development. The common beta subunit βPS and two alpha subunits, αPS2 and αPS3, are located in puncta at both glia-glia and glia-ECM interfaces. Depletion of βPS integrin and talin by RNAi impaired the migration and distribution of glia within the OS resulting in morphological defects. Reduction of integrin or talin in the glia also disrupted photoreceptor axon outgrowth leading to axon stalling in the OS and ED. The neuronal defects were correlated with a disruption of the carpet glia tube paired with invasion of glia into the core of the OS and the formation of a glial cap. Our results suggest that integrin-mediated extracellular signals are important for multiple aspects of glial development and non-autonomously affect axonal migration during Drosophila eye development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.