ArticleThe Journal of biological chemistry2014
Glucose directly promotes antifungal resistance in the fungal pathogen, Candida spp.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
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- Spatial structure of yeast biofilms and the role of cell adhesion across different media.Biofilm · 2025Article
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- Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease.Journal of fungi (Basel, Switzerland) · 2025Review
- Explainable Prediction of Long-Term Glycated Hemoglobin Response Change in Finnish Patients with Type 2 Diabetes Following Drug Initiation Using Evidence-Based Machine Learning Approaches.Clinical epidemiology · 2025Article
- Is there a difference in the expression levels of genes responsible for fluconazole resistance inCurrent medical mycology · 2025Review
- Comprehensive analysis of the pathogen spectrum and antibiotic resistance profiles in periprosthetic joint infections: a single center retrospective study.Frontiers in surgery · 2025Article
- Carbon substrates promotes stress resistance and drug tolerance in clinical isolates of Candida tropicalis.Archives of microbiology · 2024Article
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- Axenic Long-Term Cultivation ofJournal of fungi (Basel, Switzerland) · 2023Article
- Impact of host factors on susceptibility to antifungal agents.ADMET & DMPK · 2022Article
- Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management.Journal of fungi (Basel, Switzerland) · 2021Review
- Fructose Induces Fluconazole Resistance inInternational journal of molecular sciences · 2021Article
- Challenges in Antifungal Therapy in Diabetes Mellitus.Journal of clinical medicine · 2020Article
- Adapting to survive: How Candida overcomes host-imposed constraints during human colonization.PLoS pathogens · 2020Review
- Prevalence and antifungal susceptibility of gastrointestinal candidiasis among diabetic patients: A cross-sectional study.African journal of laboratory medicine · 2020Article
- Candida sp. Infections in Patients with Diabetes Mellitus.Journal of clinical medicine · 2019Review
- Influence of culture media on biofilm formation by Candida species and response of sessile cells to antifungals and oxidative stress.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of glucose on the susceptibility of antifungal agents were investigated against Candida spp. Increasing the concentration of glucose decreased the activity of antifungal agents; voriconazole was the most affected drugs followed by amphotericin B. No significant change has been observed for anidulafungin. Biophysical interactions between antifungal agents with glucose molecules were investigated using isothermal titration calorimetry, Fourier transform infrared, and (1)H NMR. Glucose has a higher affinity to bind with voriconazole by hydrogen bonding and decrease the susceptibility of antifungal agents during chemotherapy. In addition to confirming the results observed in vitro, theoretical docking studies demonstrated that voriconazole presented three important hydrogen bonds and amphotericin B presented two hydrogen bonds that stabilized the glucose. In vivo results also suggest that the physiologically relevant higher glucose level in the bloodstream of diabetes mellitus mice might interact with the available selective agents during antifungal therapy, thus decreasing glucose activity by complex formation. Thus, proper selection of drugs for diabetes mellitus patients is important to control infectious diseases.
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