Evidence map›Paper›PMID 25053365›Full record

ReviewCurrent HIV research2014

Biomedical consequences of alcohol use disorders in the HIV-infected host.

Patricia E Molina, Gregory J Bagby, Steve Nelson

Open access · greenAbstract readReview
In one paragraph

Review in Current HIV research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  7. The alcohol exposome.Alcohol (Fayetteville, N.Y.) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Patricia E Molina
Gregory J Bagby
Steve NelsonLSUHSC Physiology, 1901 Perdido St., New Orleans, LA 70112, USA. pmolin@lsuhsc.edu.
Louisiana State University Health Sciences Center New Orleans · US

Funding

Translational Research/Education ComponentP60AA009803 · NIAAA · LSU HEALTH SCIENCES CENTER · PI DAVID A WELSH · 2004 to 2026
$42.6M
BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAMT32AA007577 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PATRICIA E. MOLINA · 1999 to 2026
$9.6M
PILOT--IMPACT OF ALCOHOLISM ON AIDS ASOCIATED MUSCLE WASTINGP50AA009803 · NIAAA · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI NELSON, STEVE · 1994 to 2003
$7.2M
Regulation of Nutrient Sensing and Muscle Wasting by AlcoholR01AA011290 · NIAAA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LANG, CHARLES H. · 1997 to 2011
$3.5M
HIV/AIDS & Alcohol-Related Outcomes:Translational Evidence-Based InterventionsU01AA021995 · NIAAA · LSU HEALTH SCIENCES CENTER · PI MOLINA, PATRICIA E. · 2012 to 2016
$3.4M
Regulation of Nutrient Sensing and Muscle Wasting by AlcoholR37AA011290 · NIAAA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LANG, CHARLES H. · 2012 to 2021
$3.4M
NIAAA NIH HHS AA-11290NIAAA NIH HHS P50 AA009803NIAAA NIH HHS P60 AA009803NIAAA NIH HHS R01 AA011290NIAAA NIH HHS R37 AA011290NIAAA NIH HHS T32 AA007577NIAAA NIH HHS U01 AA021995PHS HHS NIAAA-07577PHS HHS NIAAA-09803PHS HHS UAA021995A
6 · The paper itself

Abstract

Alcohol abuse is the most common and costly form of drug abuse in the United States. It is well known that alcohol abuse contributes to risky behaviors associated with greater incidence of human immunodeficiency virus (HIV) infections. As HIV has become a more chronic disease since the introduction of antiretroviral therapy, it is expected that alcohol use disorders will have an adverse effect on the health of HIV-infected patients. The biomedical consequences of acute and chronic alcohol abuse are multisystemic. Based on what is currently known of the comorbid and pathophysiological conditions resulting from HIV infection in people with alcohol use disorders, chronic alcohol abuse appears to alter the virus infectivity, the immune response of the host, and the progression of disease and tissue injury, with specific impact on disease progression. The combined insult of alcohol abuse and HIV affects organ systems, including the central nervous system, the immune system, the liver, heart, and lungs, and the musculoskeletal system. Here we outline the major pathological consequences of alcohol abuse in the HIV-infected individual, emphasizing its impact on immunomodulation, erosion of lean body mass associated with AIDS wasting, and lipodystrophy. We conclude that interventions focused on reducing or avoiding alcohol abuse are likely to be important in decreasing morbidity and improving outcomes in people living with HIV/AIDS.

Indexed as

AIDS Dementia ComplexAlcoholismDisease ProgressionDisease Transmission, InfectiousHIVHIV-Associated Lipodystrophy SyndromeHIV InfectionsHumansRisk-TakingUnited States

Identifiers

PMID25053365
PMCPMC4222574
OpenAlexW2169521932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.