ArticleBMC genetics2014
Characterizing the genetic differences between two distinct migrant groups from Indo-European and Dravidian speaking populations in India.
Article in BMC genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study.The Lancet regional health. Southeast Asia · 2023Article
- Chronic ocular sequelae in Stevens-Johnson syndrome: a genetic association study.Molecular vision · 2022Article
- Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception cohort epidemiology study.World journal of gastroenterology · 2019Observational
- Detection and Classification of Hard and Soft Sweeps from Unphased Genotypes by Multilocus Genotype Identity.Genetics · 2018Article
- Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.Nature communications · 2017Article
- Genetic variations in the Dravidian population of South West coast of India: Implications in designing case-control studies.The Indian journal of medical research · 2017Article
- Characterising private and shared signatures of positive selection in 37 Asian populations.European journal of human genetics : EJHG · 2017Article
- Population Stratification and Underrepresentation of Indian Subcontinent Genetic Diversity in the 1000 Genomes Project Dataset.Genome biology and evolution · 2016Article
- Inflammatory bowel disease in India - Past, present and future.World journal of gastroenterology · 2016Review
- Challenges in Collating Spirometry Reference Data for South-Asian Children: An Observational Study.PloS one · 2016Observational
- Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication.Molecular ecology · 2016Review
- PON1 (Paraoxonase 1) Q192R Gene Polymorphism in Ischemic Stroke among North Indian Population.Annals of Indian Academy of NeurologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndia is home to many ethnically and linguistically diverse populations. It is hypothesized that history of invasions by people from Persia and Central Asia, who are referred as Aryans in Hindu Holy Scriptures, had a defining role in shaping the Indian population canvas. A shift in spoken languages from Dravidian languages to Indo-European languages around 1500 B.C. is central to the Aryan Invasion Theory. Here we investigate the genetic differences between two sub-populations of India consisting of: (1) The Indo-European language speaking Gujarati Indians with genome-wide data from the International HapMap Project; and (2) the Dravidian language speaking Tamil Indians with genome-wide data from the Singapore Genome Variation Project.
resultsWe implemented three population genetics measures to identify genomic regions that are significantly differentiated between the two Indian populations originating from the north and south of India. These measures singled out genomic regions with: (i) SNPs exhibiting significant variation in allele frequencies in the two Indian populations; and (ii) differential signals of positive natural selection as quantified by the integrated haplotype score (iHS) and cross-population extended haplotype homozygosity (XP-EHH). One of the regions that emerged spans the SLC24A5 gene that has been functionally shown to affect skin pigmentation, with a higher degree of genetic sharing between Gujarati Indians and Europeans.
conclusionsOur finding points to a gene-flow from Europe to north India that provides an explanation for the lighter skin tones present in North Indians in comparison to South Indians.
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