Evidence map›Paper›PMID 25053203›Full record

ArticleDiagnostic microbiology and infectious disease2014

Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.

Chulsoo Ahn, Alveena Syed, Fupin Hu, Jessica A O'Hara, Jesabel I Rivera, Yohei Doi

Open access · greenAbstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Emergence ofMicroorganisms · 2020
    Article
  2. Molecular Epidemiology of Carbapenemases inAntibiotics (Basel, Switzerland) · 2020
    Review
  3. The first report ofIranian journal of basic medical sciences · 2020
    Article
  4. Prevalence of plasmid-encoded carbapenemases in multi-drug resistantIranian journal of basic medical sciences · 2020
    Article
  5. Article
  6. Multidrug-ResistantFrontiers in microbiology · 2019
    Article
  7. Outbreak OfInfection and drug resistance · 2019
    Article
  8. Antimicrobial agents and chemotherapy · 2018
    Article
  9. Article
  10. Review
  11. Mutations inAntimicrobial agents and chemotherapy · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Carbapenemase-producing Enterobacteriaceae.Seminars in respiratory and critical care medicine · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chulsoo AhnDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alveena SyedDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Fupin HuDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, China.
Jessica A O'HaraDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jesabel I RiveraDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yohei DoiDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: yod4@pitt.edu.
University of Pittsburgh · USFudan University · CN

Funding

Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Markers predicting response to therapy for KPC-producing Klebsiella pneumoniaeR21AI107302 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2013 to 2014
$409k
NIAID NIH HHS R01 AI104895NIAID NIH HHS R01AI104895NIAID NIH HHS R21 AI107302NIAID NIH HHS R21AI107302
6 · The paper itself

Abstract

Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis showed diverse restriction patterns overall, multilocus sequence typing identified Enterobacter cloacae isolates with sequence types 93 and 171 from 2 hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin and tigecycline, and the majority, to amikacin and doxycycline. A blaKPC-carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in 3 of the isolates. Spread of blaKPC in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes.

Indexed as

AdultAgedAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-Lactam Resistancebeta-LactamsCross InfectionElectrophoresis, Gel, Pulsed-FieldEnterobacter cloacaeEnterobacteriaceae InfectionsErtapenemFemaleGenotypeHospitalsHumansAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-LactamscarbapenemaseErtapenemEnterobacter aerogenesEnterobacter cloacaeKlebsiella pneumoniae carbapenemease

Identifiers

PMID25053203
PMCPMC4164580
OpenAlexW2027171106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.