Evidence map›Paper›PMID 25052812›Full record

ReviewMolecular oral microbiology2015

Code blue: Acinetobacter baumannii, a nosocomial pathogen with a role in the oral cavity.

A M Richards, Y Abu Kwaik, R J Lamont

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

  1. Disruption ofVirulence · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Acinetobacter baumannii as an oro-dental pathogen: a red alert!!Journal of applied oral science : revista FOB · 2024
    Review
  11. Review
  12. Article
  13. Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador.International journal of environmental research and public health · 2023
    Article
  14. [Application Progress of Dual RNA Sequencing in Microbial Research].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Review
  15. Global Threat of Carbapenem-Resistant Gram-Negative Bacteria.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Article
  17. Review
  18. Infection and drug resistance · 2021
    Review
  19. Fungal-Bacterial Interactions in Health and Disease.Pathogens (Basel, Switzerland) · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

A M RichardsDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA.
Y Abu Kwaik
R J Lamont
University of Louisville · US

Funding

MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
Streptococcus-Candida Communication in Oral BiofilmsR01DE016690 · NIDCR · UNIVERSITY OF BRISTOL · PI JENKINSON, HOWARD F, LAMONT, RICHARD J · 2006 to 2016
$3.8M
P.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6M
Role of JAKs in innate responses to P. gingivalisR01DE017921 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2010 to 2019
$3.3M
Modulation of apoptosis by Legionella PneumophilaR01AI069321 · NIAID · UNIVERSITY OF LOUISVILLE · PI ABU KWAIK, YOUSEF A · 2007 to 2011
$1.8M
Pathogenic mechanisms of F. alocisR21DE022867 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2012 to 2013
$404k
Farnesylated effectors of LegionellaR21AI107978 · NIAID · UNIVERSITY OF LOUISVILLE · PI ABU KWAIK, YOUSEF A · 2013 to 2014
$399k
NIAID NIH HHS AI069321NIAID NIH HHS AI107978NIAID NIH HHS R01 AI069321NIAID NIH HHS R21 AI107978NIDCR NIH HHS DE011111NIDCR NIH HHS DE012505NIDCR NIH HHS DE016690NIDCR NIH HHS DE017921NIDCR NIH HHS DE022867NIDCR NIH HHS DE023193NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE016690NIDCR NIH HHS R01 DE017921NIDCR NIH HHS R01 DE023193NIDCR NIH HHS R21 DE022867NIDCR NIH HHS R37 DE011111
6 · The paper itself

Abstract

Actinetobacter baumannii is an important nosocomial pathogen that can cause a wide range of serious conditions including pneumonia, meningitis, necrotizing fasciitis and sepsis. It is also a major cause of wound infections in military personnel injured during the conflicts in Afghanistan and Iraq, leading to its popular nickname of 'Iraqibacter'. Contributing to its success in clinical settings is resistance to environmental stresses such as desiccation and disinfectants. Moreover, in recent years there has been a dramatic increase in the number of A. baumannii strains with resistance to multiple antibiotic classes. Acinetobacter baumannii is an inhabitant of oral biofilms, which can act as a reservoir for pneumonia and chronic obstructive pulmonary disease. Subgingival colonization by A. baumannii increases the risk of refractory periodontitis. Pathogenesis of the organism involves adherence, biofilm formation and iron acquisition. In addition, A. baumannii can induce apoptotic cell death in epithelial cells and kill hyphal forms of Candida albicans. Virulence factors that have been identified include pili, the outer membrane protein OmpA, phospholipases and extracellular polysaccharide. Acinetobacter baumannii can sense blue light through a blue-light sensing using flavin (BLUF) domain protein, BlsA. The resulting conformational change in BlsA leads to changes in gene expression, including virulence genes.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsApoptosisBacterial AdhesionBiofilmsCross InfectionDrug Resistance, BacterialHumansIronLightMicrobial InteractionsMouthPeriodontitisVirulenceVirulence FactorsIronVirulence FactorsAcinetobacterinfection modelsoral microbiologyperiodontal diseaserespiratory tract microbiology

Identifiers

PMID25052812
PMCPMC4617346
OpenAlexW2014612798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.