ArticleProceedings of the National Academy of Sciences of the United States of America1989
Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire.BMC immunology · 2014Article
- Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Early Vlambda diversification in sheep.Immunology · 2001Article
- A recombinant single chain antibody neutralizes coronavirus infectivity but only slightly delays lethal infection of mice.European journal of immunology · 1997Article
- Molecular cloning, expression, and characterization of a functional single-chain Fv antibody to the mycotoxin zearalenone.Applied and environmental microbiology · 1997Article
- Idiotypic diversity and variable region gene usage by mouse anti-HLA-DQ3 mAb.Immunogenetics · 1995Article
- Immunoglobulin light chain class multiplicity and alternative organizational forms in early vertebrate phylogeny.Immunogenetics · 1994Article
- Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.The Journal of experimental medicine · 1993Article
- Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.The Journal of experimental medicine · 1992Article
- Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes.The Journal of experimental medicine · 1991Article
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.The Journal of experimental medicine · 1991Article
- Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles.The Journal of experimental medicine · 1991Article
- Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes.Immunogenetics · 1991Article
- Two closely related kappa variable region pseudogenes pose an evolutionary paradox.Immunogenetics · 1991Article
- The physical organization of the human immunoglobulin heavy chain gene complex.The EMBO journal · 1990Article
- A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.The Journal of experimental medicine · 1990Article
- Pairing of VK and VK gene families in self-reactive antibodies.Journal of clinical immunology · 1990Review
- Preferential rearrangement of V kappa 4 gene segments in pre-B cell lines.The Journal of experimental medicine · 1990Article
- Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells.Molecular and cellular biology · 1990Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Immunoglobulin heavy-chain variable region (TH) gene segments located closest to the joining (JH) gene segments are preferentially rearranged during ontogeny, indicating that chromosomal position influences the frequency of rearrangement. In addition, certain VH gene segments are repeatedly rearranged, suggesting that the DNA sequence or structure surrounding these segments may increase the probability of rearrangement. To determine whether there is similar based rearrangement of kappa variable (V kappa) gene segments, 25 rearrangements were sequenced from murine fetal and neonatal B-cell hybridomas and from subclones of a pre-B cell line that rearranged V kappa genes during in vitro culture. Four gene segments were isolated twice and one gene segment was isolated three times, suggesting that the process that targets individual variable gene segments for repeated rearrangement operates on both the VH and V kappa loci. Based on a current map of the V kappa locus, the rearranged gene segments belong to nine families that are dispersed throughout the locus. Thus, in these cell types, V kappa rearrangements use germ-line gene segments located across the entire locus, whereas the corresponding VH rearrangements use gene segments proximal to the JH gene segments. Heterogeneity of V kappa rearrangements would add diversity to the biased pool of VH rearrangements, producing a broad repertoire of antibodies early in development.
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