Trial reportRadiation oncology (London, England)2014
Weight and body mass index in relation to irradiated volume and to overall survival in patients with oropharyngeal cancer: a retrospective cohort study.
Trial report in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06860425 (Use of a Comprehensive, Mobile Application to Assist Cancer Patients With Diet, Nutrition and Activity), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of a Comprehensive, Mobile Application to Assist Cancer Patients With Diet, Nutrition and Activity
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic impact of weight loss during radiation therapy in patients with head and neck cancer: A systematic review.Nutrition and health · 2026Pooled it
- Positive Effect of Higher Adult Body Mass Index on Overall Survival of Digestive System Cancers Except Pancreatic Cancer: A Systematic Review and Meta-Analysis.BioMed research international · 2017Pooled it
- Dose-dependent effects of radiotherapy on body composition, nutritional status, and clinical symptoms in head and neck cancer.Scientific reports · 2026Article
- Energy Adequacy of Planned Diets in Institutionalized Older Adults: A Scenario Analysis Based on Requirements from Indirect Calorimetry.Nutrients · 2026Article
- Impact of pretreatment body mass index on the survival of head and neck cancer patients.Head & neck · 2024Article
- Predicting Nomogram for Severe Oral Mucositis in Patients with Nasopharyngeal Carcinoma during Intensity-Modulated Radiation Therapy: A Retrospective Cohort Study.Current oncology (Toronto, Ont.) · 2022Article
- Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein.Cancers · 2022Article
- Article
- Can Bioelectrical Impedance Analysis and BMI be a Prognostic Tool in Head and Neck Cancer Patients? A Review of the Evidence.Cancers · 2020Review
- Disease-induced and treatment-induced alterations in body composition in locally advanced head and neck squamous cell carcinoma.Journal of cachexia, sarcopenia and muscle · 2020Article
- Weight loss as a prognostic factor for recurrence and survival in oropharyngeal squamous cell carcinoma patients.Molecular and clinical oncology · 2018Article
- The impact of dietary regimen compliance on outcomes for HNSCC patients treated with radiation therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma.Oral oncology · 2016Review
- Article
- Feasibility of Non-invasive Brain Modulation for Management of Pain Related to Chemoradiotherapy in Patients with Advanced Head and Neck Cancer.Frontiers in human neuroscience · 2016Article
- Evaluation of effect of body mass index and weight loss on survival of patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy.Radiation oncology (London, England) · 2015Article
- Obesity in patients with carcinoma cervix increases the risk of adverse events.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
- Commentary.Indian journal of palliative careArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight loss is a common problem in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) treated with radiotherapy (RT). The aims of the present study were to determine if treated volume (TV), as a measure of the radiation dose burden, can predict weight loss in patients with oropharyngeal cancer and to analyze weight loss and body mass index (BMI) in the same patient group in relation to 5-year overall survival.
methodsThe ARTSCAN trial is a prospective, randomized, multicenter trial in patients with SCCHN. Nutritional data from the ARTSCAN trial were analyzed retrospectively using univariate and multivariate statistical methods based on information on percentage weight loss from the start of RT up to five months after the termination of RT (study cohort 1, n = 232) and information on patients' BMI at the start of RT (study cohort 2, n = 203). TV was defined as the volume of the patient receiving at least 95% of the prescribed dose. TV64.6 Gy encompasses macroscopic tumor and TV43.7 Gy elective lymph nodes of the neck.
resultsTV64.6 Gy and TV43.7 Gy were both significantly correlated with higher weight loss up to five months after the termination of RT in study cohort 1 (p < 0.001 for both). BMI at the start of RT was shown to be a prognostic factor for 5-year overall survival in study cohort 2 but weight loss was not. The hazard ratios and 95% confidence intervals were 3.78 (1.46-9.75) and 2.57 (1.43-4.62) in patients with underweight and normal weight, respectively.
conclusionsTV can predict weight loss during RT in patients with oropharyngeal cancer regardless of clinical stage. A high BMI (>25 kg/m2) at the start of RT is positively associated with survival in patients with oropharyngeal cancer.
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