ArticlePhysiological genomics2014
Acclimatization to long-term hypoxia: gene expression in ovine carotid arteries.
Article in Physiological genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Transcriptomic insights into the immune responses of the lung and muscle of non-healthy harbor porpoises (Frontiers in immunology · 2026Article
- RNA-seq analysis of blood from cave- and surface-dwellingFrontiers in physiology · 2025Article
- Sexual dimorphic gene expression profile of perirenal adipose tissue in ovine fetuses with growth restriction.Frontiers in physiology · 2023Article
- Suprabasin-A Review.Genes · 2021Review
- Transcriptomic Changes in Young Japanese Males After Exposure to Acute Hypobaric Hypoxia.Frontiers in genetics · 2020Article
- Angiogenic Transformation in Human Brain Micro Endothelial Cells: Whole Genome DNA Methylation and Transcriptomic Analysis.Frontiers in physiology · 2019Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Developmental Maturation and Alpha-1 Adrenergic Receptors-Mediated Gene Expression Changes in Ovine Middle Cerebral Arteries.Scientific reports · 2018Article
- Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia.Frontiers in physiology · 2018Article
- Comparative and Experimental Studies on the Genes Altered by Chronic Hypoxia in Human Brain Microendothelial Cells.Frontiers in physiology · 2017Article
- LncRNA as a Therapeutic Target for Angiogenesis.Current topics in medicinal chemistry · 2017Review
- Microarray gene expression analysis in ovine ductus arteriosus during fetal development and birth transition.Pediatric research · 2016Article
- Metabolic Profiles in Ovine Carotid Arteries with Developmental Maturation and Long-Term Hypoxia.PloS one · 2015Article
- Cerebral artery alpha-1 AR subtypes: high altitude long-term acclimatization responses.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to acute high-altitude hypoxia is associated with an increase in cerebral blood flow (CBF) as a consequence of low arterial O2 tension. However, in response to high altitude acclimatization, CBF returns to levels similar to those at sea level, and tissue blood flow is maintained by an increase in angiogenesis. Of consequence, dysregulation of the acclimatization responses and CBF can result in acute mountain sickness, acute cerebral and/or pulmonary edema. To elucidate the signal transduction pathways involved in successful acclimatization to high altitude, in ovine carotid arteries, we tested the hypothesis that high altitude-associated long-term hypoxia results in changes in gene expression of critical signaling pathways. We acclimatized nonpregnant adult sheep to 3,801 m altitude for ∼110 days and conducted oligonucleotide microarray experiments on carotid arteries. Of a total of 116 regulated genes, 58 genes were significantly upregulated and 58 genes were significantly downregulated (each >2-fold, P < 0.05). Major upregulated genes included suprabasin and myelin basic protein, whereas downregulated genes included BAG2. Several of these genes are known to activate the ERK canonical signal transduction pathway and the process of angiogenesis. We conclude that among other changes, the altered signal transduction molecules involved in high-altitude acclimatization are associated ERK activation and angiogenesis.
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