Trial reportTrials2014
Baclofen for stroke patients with persistent hiccups: a randomized, double-blind, placebo-controlled trial.
Trial report in Trials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.The Cochrane database of systematic reviews · 2018Pooled it
- Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.The Cochrane database of systematic reviews · 2016Pooled it
- End-Stage Renal Disease Patient on Hemodialysis With Baclofen-Related Neurotoxicity and Pancreatitis.Case reports in nephrology · 2026Article
- Article
- Evaluation of factors associated with clinically problematic hiccups in cisplatin-containing treatment with dexamethasone and neurokinin 1 receptor antagonists.International journal of clinical oncology · 2025Article
- Article
- Experience of illness with chronic singultus: a qualitative interview study.Orphanet journal of rare diseases · 2025Article
- Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial.Frontiers in neurology · 2025Article
- Interventions for Hiccups in Adults: A Scoping Review of Western and Eastern Approaches.Palliative medicine reports · 2025Article
- Review
- Article
- Hiccups in patients with cancer: a multi-site, single-institution study of etiology, severity, complications, interventions, and outcomes.BMC cancer · 2022Article
- Persistent hiccups - A rare complication of suprahepatic inferior vena cava stenting.BMJ case reports · 2021Article
- Baclofen therapeutics, toxicity, and withdrawal: A narrative review.SAGE open medicine · 2021Review
- Sustained Baclofen-Induced Activation of GABAFrontiers in molecular neuroscience · 2021Article
- Chronic Hiccups.Current treatment options in gastroenterology · 2020Review
- Acupuncture for hiccups: A systematic review protocol of high-quality randomized trials.Medicine · 2019Article
- Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.BMC nephrology · 2018Article
- Anterior and posterior diaphragm kinesio taping for intractable hiccups after ischemic stroke: A case report.Medicine · 2018Article
- Comparison the Effects of Ephedrine and Lidocaine in Treatment of Intraoperative Hiccups in Gynecologic Surgery under Sedation.Advanced biomedical research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups. This study was aimed to assess the possible efficacy of baclofen for the treatment of persistent hiccups after stroke.
methodsIn total, 30 stroke patients with persistent hiccups were randomly assigned to receive baclofen (n = 15) or a placebo (n = 15) in a double-blind, parallel-group trial. Participants in the baclofen group received 10 mg baclofen 3 times daily for 5 days. Participants assigned to the placebo group received 10 mg placebo 3 times daily for 5 days. The primary outcome measure was cessation of hiccups. Secondary outcome measures included efficacy in the two groups and adverse events.
resultsAll 30 patients completed the study. The number of patients in whom the hiccups completely stopped was higher in the baclofen group than in the placebo group (relative risk, 7.00; 95% confidence interval, 1.91-25.62; P = 0.003). Furthermore, efficacy was higher in the baclofen group than in the placebo group (P < 0.01). No serious adverse events were documented in either group. One case each of mild transient drowsiness and dizziness was present in the baclofen group.
conclusionsBaclofen was more effective than a placebo for the treatment of persistent hiccups in stroke patients.
trial registrationChinese Clinical Trials Register: ChiCTR-TRC-13004554.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.