Evidence map›Paper›PMID 25052229›Full record

Trial reportEuropean journal of clinical nutrition2014

Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults.

A J Cox, N P West, P L Horn, M J Lehtinen, G Koerbin, D B Pyne, S J Lahtinen, P A Fricker, A W Cripps

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Enhanced editing ofApplied and environmental microbiology · 2026
    Article
  3. Article
  4. The Effect ofMicroorganisms · 2023
    Article
  5. Review
  6. Effect ofEClinicalMedicine · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. The effects of probiotic supplement on hemoglobin in chronic renal failure patients under hemodialysis: A randomized clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

A J Cox1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] School of Medical Science, Griffith University, Southport, QLD, Australia.
N P West1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] School of Medical Science, Griffith University, Southport, QLD, Australia.
P L HornDepartment of Physiology, Australian Institute of Sport, Canberra, ACT, Australia.
M J LehtinenDuPont Nutrition & Health, Danisco Sweeteners Oy, Active Nutrition, Kantvik, Finland.
G KoerbinACT Pathology, Canberra, ACT, Australia.
D B PyneDepartment of Physiology, Australian Institute of Sport, Canberra, ACT, Australia.
S J LahtinenDuPont Nutrition & Health, Danisco Sweeteners Oy, Active Nutrition, Kantvik, Finland.
P A Fricker1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] Australian Institute of Sport, Canberra, ACT, Australia.
A W Cripps1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] School of Medical Science, Griffith University, Southport, QLD, Australia.
Griffith University · AUDuPont (Finland) · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Use of probiotic-containing foods and probiotic supplements is increasing; however, few studies document safety and tolerability in conjunction with defined clinical end points. This paper reports the effects of 150 days of supplementation with either a single- (Bifidobacterium animalis subsp. lactis Bl-04) or a double-strain (Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07) probiotic on routine haematology and clinical chemistry measures in healthy active adults. Pre- to post-intervention changes in laboratory measures were determined and compared between supplement and placebo groups. Overall there were few differences in routine haematology and clinical chemistry measures between supplement and placebo groups post-intervention. Exceptions included plasma calcium (P=0.03) and urea (P=0.015); however, observed changes were small and within assay-specific laboratory reference ranges. These data provide evidence supporting the use of these probiotic supplements over a period of 5 months in healthy active adults without obvious safety or tolerability issues.

Indexed as

Dietary SupplementsAdolescentAdultBifidobacteriumBlood Chemical AnalysisCalciumDouble-Blind MethodFemaleHealthy VolunteersHematologyHumansLactobacillus acidophilusMaleMiddle AgedProbioticsUreaCalciumUrea

Identifiers

PMID25052229
OpenAlexW2049309486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.