ArticleNeuromolecular medicine2014
Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions.
Article in Neuromolecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- Peripheral Blood-Based Gene Expression Studies in Schizophrenia: A Systematic Review.Frontiers in genetics · 2021Pooled it
- Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings.Molecular psychiatry · 2020Pooled it
- Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review.BMC genetics · 2016Pooled it
- DNMT gene expression in peripheral leukocytes in schizophrenia and correlations with one-carbon metabolites: folate, total homocysteine, and vitamin B6.Frontiers in psychiatry · 2025Article
- Impacts of Polyenvironmental Factors on DNA Methylation in Patients With Psychosis.Schizophrenia bulletin open · 2025Article
- Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo.Nature communications · 2024Article
- Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia.Frontiers in psychiatry · 2024Article
- Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions.Science advances · 2023Article
- Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA.Human brain mapping · 2022Review
- Epigenetic Age Acceleration Was Delayed in Schizophrenia.Schizophrenia bulletin · 2021Article
- SZDB2.0: an updated comprehensive resource for schizophrenia research.Human genetics · 2020Article
- Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality.Frontiers in psychiatry · 2020Review
- The effect of age on DNA methylation in whole blood among Bangladeshi men and women.BMC genomics · 2019Article
- Insights from deconvolution of cell subtype proportions enhance the interpretation of functional genomic data.PloS one · 2019Article
- Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia.International journal of molecular sciences · 2017Article
- Epigenome-wide association study of DNA methylation in panic disorder.Clinical epigenetics · 2017Article
- Article
- An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.Genome biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation, which is the transference of a methyl group to the 5'-carbon position of the cytosine in a CpG dinucleotide, is one of the major mechanisms of epigenetic modifications. A number of studies have demonstrated altered DNA methylation of peripheral blood cells in schizophrenia (SCZ) in previous studies. However, most of these studies have been limited to the analysis of the CpG sites in CpG islands in gene promoter regions, and cell-type proportions of peripheral leukocytes, which may be one of the potential confounding factors for DNA methylation, have not been adjusted in these studies. In this study, we performed a genome-wide DNA methylation profiling of the peripheral leukocytes from patients with SCZ and from non-psychiatric controls (N = 105; 63 SCZ and 42 control subjects) using a quantitative high-resolution DNA methylation microarray which covered across the whole gene region (485,764 CpG dinucleotides). In the DNA methylation data analysis, we first estimated the cell-type proportions of each sample with a published algorithm. Next, we performed a surrogate variable analysis to identify potential confounding factors in our microarray data. Finally, we conducted a multiple linear regression analysis in consideration of these factors, including estimated cell-type proportions, and identified aberrant DNA methylation in SCZ at 2,552 CpG loci at a 5% false discovery rate correction. Our results suggest that altered DNA methylation may be involved in the pathophysiology of SCZ, and cell heterogeneity adjustments may be necessary for DNA methylation analysis.
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Registered trials
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