Evidence map›Paper›PMID 25051501›Full record

ArticlePLoS medicine2014

Mortality after parental death in childhood: a nationwide cohort study from three Nordic countries.

Jiong Li, Mogens Vestergaard, Sven Cnattingius, Mika Gissler, Bodil Hammer Bech, Carsten Obel, Jørn Olsen

Open access · goldAbstract read
In one paragraph

Article in PLoS medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
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  3. The Aarhus bereavement study (TABstudy).European journal of epidemiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Jiong LiSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Mogens VestergaardSection for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark; Research Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark.
Sven CnattingiusClinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Mika GisslerNational Institute for Health and Welfare (THL), Helsinki, Finland.
Bodil Hammer BechSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Carsten ObelSection for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark; Research Programme for Mental Child Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Jørn OlsenSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Epidemiology, School of Public Health, University of California, Los Angeles, California, United States of America.
Aarhus University · DKFinnish Institute for Health and Welfare · FIKarolinska Institutet · SEUniversity of California, Los Angeles · US

Funding

Medical Research Council MR/K006525/1
6 · The paper itself

Abstract

backgroundBereavement by spousal death and child death in adulthood has been shown to lead to an increased risk of mortality. Maternal death in infancy or parental death in early childhood may have an impact on mortality but evidence has been limited to short-term or selected causes of death. Little is known about long-term or cause-specific mortality after parental death in childhood. METHODS AND

findingsThis cohort study included all persons born in Denmark from 1968 to 2008 (n = 2,789,807) and in Sweden from 1973 to 2006 (n = 3,380,301), and a random sample of 89.3% of all born in Finland from 1987 to 2007 (n = 1,131,905). A total of 189,094 persons were included in the exposed cohort when they lost a parent before 18 years old. Log-linear Poisson regression was used to estimate mortality rate ratio (MRR). Parental death was associated with a 50% increased all-cause mortality (MRR = 1.50, 95% CI 1.43-1.58). The risks were increased for most specific cause groups and the highest MRRs were observed when the cause of child death and the cause of parental death were in the same category. Parental unnatural death was associated with a higher mortality risk (MRR = 1.84, 95% CI 1.71-2.00) than parental natural death (MRR = 1.33, 95% CI 1.24-1.41). The magnitude of the associations varied according to type of death and age at bereavement over different follow-up periods. The main limitation of the study is the lack of data on post-bereavement information on the quality of the parent-child relationship, lifestyles, and common physical environment.

conclusionsParental death in childhood or adolescence is associated with increased all-cause mortality into early adulthood. Since an increased mortality reflects both genetic susceptibility and long-term impacts of parental death on health and social well-being, our findings have implications in clinical responses and public health strategies. Please see later in the article for the Editors' Summary.

Indexed as

Child MortalityInfant MortalityLife Change EventsAdolescentBereavementCause of DeathChildChild, PreschoolCohort StudiesDenmarkFemaleFinlandHumansInfantMaleParental Death

Identifiers

PMID25051501
PMCPMC4106717
OpenAlexW2005930472

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.