ArticleEndocrinology2014
Cnr2 deficiency confers resistance to inflammation-induced preterm birth in mice.
Article in Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- A Combination ofNutrients · 2025Article
- Placental Cannabinoid Receptor Expression in Preterm Birth.Journal of pregnancy · 2024Observational
- Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2.Signal transduction and targeted therapy · 2022Article
- Maternal regulation of inflammatory cues is required for induction of preterm birth.JCI insight · 2020Article
- Toll-like receptor 2/4 inhibitors can reduce preterm birth in mice.The Journal of international medical research · 2020Article
- Differential outcomes of TLR2 engagement in inflammation-induced preterm birth.Journal of leukocyte biology · 2018Article
- Article
- Targeting Cannabinoid Signaling in the Immune System: "High"-ly Exciting Questions, Possibilities, and Challenges.Frontiers in immunology · 2017Review
- Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth.Scientific reports · 2016Article
- Interleukin-10: a pleiotropic regulator in pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Review
- The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids.Gut microbesArticle
- THE INFLUENCE OF ENDOCANNABINOID SYSTEM ON WOMEN REPRODUCTION.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Roles of lipid mediators in early pregnancy events.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Infection-induced inflammation, frequently associated with increased production of proinflammatory cytokines, is considered a significant contributor to preterm birth. A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses. We show here that Cnr2, but not Cnr1, deficient mice are resistant to lipopolysaccharide (LPS)-driven preterm birth and suppression of serum progesterone levels. After LPS challenge, Cnr2(-/-) mice exhibited increased serum levels of IL-10 with decreased IL-6 levels. These changes were associated with reduced LPS-induced Ptgs2 expression at the maternal-conceptus interface on day 16 of pregnancy. LPS stimulation of Cnr2(-/-) dendritic cells in vitro resulted in increased IL-10 with reduced IL-6 production and correlated with increased cAMP accumulation. Collectively, our results suggest that increased IL-10 production occurring via augmented cAMP accumulation represents a potential mechanism for the resistance of Cnr2(-/-) mice to LPS-induced preterm birth. These results may have clinical relevance, because currently, there are limited options to prevent preterm birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.