ArticlePloS one2014
Population dynamics of a Salmonella lytic phage and its host: implications of the host bacterial growth rate in modelling.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Live and let die: Lysis time variability and resource limitation shape lytic bacteriophage fitness.PLoS computational biology · 2026Article
- Bridging the gap: Phage manufacturing processes from laboratory to agri-food industry.Virus research · 2025Review
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- A novel lytic phage infecting MDRFrontiers in microbiology · 2024Article
- An Edible Biopolymeric Microcapsular Wrapping Integrating Lytic Bacteriophage Particles forAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Article
- Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage.mSystems · 2022Article
- NovelMicroorganisms · 2022Article
- Physiological properties of indigenous lytic bacteriophages as monophage suspension and cocktail against poultry-adapted typhoidalVeterinary research forum : an international quarterly journal · 2022Article
- Phenotypic flux: The role of physiology in explaining the conundrum of bacterial persistence amid phage attack.Virus evolution · 2022Review
- The Bacteriophage Pf-10-A Component of the Biopesticide "Multiphage" Used to Control Agricultural Crop Diseases Caused byViruses · 2021Article
- Classification of In Vitro Phage-Host Population Growth Dynamics.Microorganisms · 2021Article
- Genomic and functional characterization of five novel Salmonella-targeting bacteriophages.Virology journal · 2021Article
- Bacteriophage: A Useful Tool for Studying Gut Bacteria Function of Housefly Larvae, Musca domestica.Microbiology spectrum · 2021Article
- Polyvalent Phage CoNShP-3 as a Natural Antimicrobial Agent Showing Lytic and Antibiofilm Activities against Antibiotic-Resistant Coagulase-Negative Staphylococci Strains.Foods (Basel, Switzerland) · 2020Article
- The Virulence Index: A Metric for Quantitative Analysis of Phage Virulence.PHAGE (New Rochelle, N.Y.) · 2020Article
- Formation of phage lysis patterns and implications on co-propagation of phages and motile host bacteria.PLoS computational biology · 2020Article
- Efficiency of Phage φ6 for Biocontrol ofMicroorganisms · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence and impact of bacteriophages in the ecology of bacterial communities coupled with their ability to control pathogens turn essential to understand and predict the dynamics between phage and bacteria populations. To achieve this knowledge it is essential to develop mathematical models able to explain and simulate the population dynamics of phage and bacteria. We have developed an unstructured mathematical model using delay-differential equations to predict the interactions between a broad-host-range Salmonella phage and its pathogenic host. The model takes into consideration the main biological parameters that rule phage-bacteria interactions likewise the adsorption rate, latent period, burst size, bacterial growth rate, and substrate uptake rate, among others. The experimental validation of the model was performed with data from phage-interaction studies in a 5 L bioreactor. The key and innovative aspect of the model was the introduction of variations in the latent period and adsorption rate values that are considered as constants in previous developed models. By modelling the latent period as a normal distribution of values and the adsorption rate as a function of the bacterial growth rate it was possible to accurately predict the behaviour of the phage-bacteria population. The model was shown to predict simulated data with a good agreement with the experimental observations and explains how a lytic phage and its host bacteria are able to coexist.
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