Evidence map›Paper›PMID 25051173›Full record

Trial reportApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2014

Effects of pomegranate extract on blood flow and running time to exhaustion.

Eric T Trexler, Abbie E Smith-Ryan, Malia N Melvin, Erica J Roelofs, Hailee L Wingfield

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eric T TrexlerDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Abbie E Smith-Ryan
Malia N Melvin
Erica J Roelofs
Hailee L Wingfield
University of North Carolina at Chapel Hill · US

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)KL2TR001109 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$5.7M
NCATS NIH HHS 1KL2TR001109NCATS NIH HHS KL2 TR001109
6 · The paper itself

Abstract

Recent research has shown that dietary nitrate has favorable effects on blood flow and exercise performance. The purpose of this randomized, double-blind, placebo-controlled crossover study was to investigate the acute effects of pomegranate extract on blood flow, vessel diameter, and exercise performance in active individuals. Nineteen men and women (mean ± SD: age, 22.2 ± 2.2 years; height, 174.8 ± 10.7 cm; body mass, 71.9 ± 13.5 kg) were randomly assigned to a placebo (PL) or pomegranate extract (PE) group. Participants performed a maximal oxygen consumption treadmill test to determine peak velocity (PV). Participants returned after 24-48 h and ingested either PL or PE. Brachial artery blood flow was assessed using ultrasound at baseline and 30 min post-ingestion (30minPI). Three treadmill runs to exhaustion were performed at 90%, 100%, and 110% PV. Blood flow was assessed immediately after each exercise bout and 30 min postexercise (30minPEx). After a 7-10 day washout, participants repeated the same procedures, ingesting the opposite supplement. Separate repeated measures ANOVAs were performed for blood flow, vessel diameter, and time to exhaustion (TTE). Blood flow was significantly augmented (p = 0.033) 30minPI with PE in comparison with PL. Vessel diameter was significantly larger (p = 0.036) 30minPEx with PE. Ingestion of PE was found to significantly augment TTE at 90% (p = 0.009) and 100% PV (p = 0.027). Acute ingestion of PE 30 min before exercise may enhance vessel diameter and blood flow and delay fatigue during exercise. Results of the current study indicate that PE is ergogenic for intermittent running, eliciting beneficial effects on blood flow.

Indexed as

LythraceaeCross-Over StudiesDouble-Blind MethodExerciseExercise ToleranceFatigueFemaleHumansMalePlant ExtractsRegional Blood FlowRunningTime FactorsYoung AdultPlant Extractsdiamètre vasculaireefficacité mitochondrialeexercise hyperemiaexercise toleranceflow-mediated dilationhyperhémie d’effortmitochondrial efficiencynitratenitric oxidenitriteoxyde nitriquepolyphenolpolyphénoltolérance à l’effortvasodilatationvasodilatation dépendante du flux sanguinvasodilationvessel diameter

Identifiers

PMID25051173
PMCPMC4146683
OpenAlexW2148440536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.