ArticleNaunyn-Schmiedeberg's archives of pharmacology1989
Effects of calcium entry blocking agents on 5-hydroxytryptamine- and noradrenaline-induced contractions of rat isolated jugular vein and aorta.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Actions of alpha-adrenoceptor blocking agents on two types of intracellular calcium stores mobilized by noradrenaline in rat aorta.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
- Different and common intracellular calcium-stores mobilized by noradrenaline and caffeine in vascular smooth muscle.Naunyn-Schmiedeberg's archives of pharmacology · 1992Article
- Angiotensin II-induced increase in slowly exchanging 45Ca2+ in relation to contractile responses of rat and guinea-pig aorta.Naunyn-Schmiedeberg's archives of pharmacology · 1991Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We calculated the contribution of the intracellular releasable calcium pool to the contractile responses induced by 5-hydroxytryptamine (5-HT) and noradrenaline (NA) by constructing time-response curves to the agonists in Ca2+-deficient medium in the isolated rat jugular vein and aorta. Biexponential curves were obtained compatible with a two compartment model. In the aorta the intracellular calcium pools are likely to be different for both 5-HT and NA. Moreover, we investigated the effect of maximally effective concentrations of calcium entry blocking agents (CEB's) on K+, 5-HT- and NA-induced contractions in Ca2+-containing medium. Only a moderate inhibiting effect of nifedipine, diltiazem, flunarizine and gallopamil on 5-HT- and NA-induced Ca2+ influx could be observed; in contrast, K+-induced Ca2+ influx could be antagonized completely. The calculated contribution of intracellular Ca2+ to 5-HT- and NA-induced contractions, obtained from the experiments in Ca2+-"free" medium was much lower than that obtained after pretreatment with CEB's, leading to the conclusion that after CEB-pretreatment a Ca2+ influx component persists. This hypothesis was supported by the observation that contractions in Ca2+-"free" medium consist of a monophasic, fast response only, whereas after CEB-pretreatment a response similar to the control, including a slow, sustained component, was obtained. The Ca2+ influx component not affected by maximally effective concentrations of CEB's seems to represent an inflow of extracellular Ca2+ directly into the cytosol and not into an intracellular calcium store.
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Registered trials
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