ArticlePloS one2014
Evidence of hepatitis A virus person-to-person transmission in household outbreaks.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies.World journal of virology · 2025Review
- Regional and age related variations in hepatitis A virus incidence in China 2004 to 2018: a descriptive epidemiological study.Scientific reports · 2025Article
- Article
- Increase in Hepatitis A Cases Linked to Imported Strains to Rio de Janeiro, Brazil: A Cross-Sectional Study.Viruses · 2022Article
- Article
- Article
- Hepatitis A virus survival on drug paraphernalia.Journal of viral hepatitis · 2020Article
- Epidemiological investigation on hepatitis A virus infection outbreak in the area of Rzeszow city during the years 2017/18.Clinical and experimental hepatology · 2020Article
- High prevalence of hepatitis A in indigenous population in north Brazil.BMC research notes · 2020Article
- Oral fluid testing facilitates understanding of hepatitis A virus household transmission.Epidemiology and infection · 2019Article
- Low occurrence of Hepatitis A virus in water samples from an urban area of Southern Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- Seropositivity of Hepatitis A in Children Aged 7-14 Years in Diyarbakir Province Center.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Effectiveness of hepatitis A vaccination as post-exposure prophylaxis.Human vaccines & immunotherapeutics · 2017Article
- Changes in cellular proliferation and plasma products are associated with liver failure.World journal of hepatology · 2016Article
- Declining Trend of Hepatitis A Seroepidemiology in Association with Improved Public Health and Economic Status of Thailand.PloS one · 2016Article
- Seroprevalence of hepatitis a and associated factors among 1-15 year old children in Eastern Turkey.International journal of clinical and experimental medicine · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The person-to-person transmission of the hepatitis A virus primarily occurs in enclosed spaces, particularly in the presence of inadequate hygiene conditions and a high proportion of susceptible individuals. Thus, intimate family contact stands out as a risk factor for HAV infection dissemination. The present study aimed to evaluate the occurrence of household HAV transmission. Blood samples were collected from patients with hepatitis A (index cases) and their family members (contacts) that were referred to an ambulatory care clinic specializing in viral hepatitis. A total of 97 samples were collected from 30 families with a confirmed hepatitis A case (index case). Serological and molecular techniques for the diagnosis of hepatitis A were conducted on all samples. HAV infection (anti-HAV IgM + and/or HAV RNA +) was detected in 34.3% (23/67) of the contacts; 34.3% (23/67) of the contacts were immune to HAV, and 31.4% (21/67) were susceptible. In the household contacts, HAV immunity was significantly associated with older age; susceptibility to infection and HAV infection were associated with younger age. Household outbreaks were detected in 16/30 families studied. Co-circulation of subgenotypes IA and IB was found in the household outbreaks, and person-to-person transmission was evidenced in six of the household outbreaks, with 100% homology between the index case and contact strains. The results demonstrated the relevance of HAV household transmission, reaffirming the need for hepatitis A vaccine administration in susceptible contacts and effective infection control procedures to prevent the extension of household outbreaks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.