ArticleHuman brain mapping2014
Longitudinal white matter changes in frontotemporal dementia subtypes.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Morphometric MRI as a diagnostic biomarker of frontotemporal dementia: A systematic review to determine clinical applicability.NeuroImage. Clinical · 2018Pooled it
- Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials.Brain : a journal of neurology · 2019Trial
- Disrupted interhemispheric communication in primary progressive aphasia: a multimodal MRI study of homotopic connectivity.NeuroImage. Clinical · 2026Article
- Altered amygdala structural connectivity and relations to social cognition in frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Fixel-based analysis reveals detailed white matter changes in semantic dementia.Brain structure & function · 2026Article
- Associations of local white matter geometry with network efficiency, macrostructural abnormalities, and clinical severity in behavioural variant frontotemporal dementia.Brain communications · 2026Article
- MRI-DTI Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia.European journal of neurology · 2025Article
- Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia.Journal of neurology · 2025Article
- Frontotemporal dementia characterization using neurite orientation dispersion and density imaging.Brain communications · 2025Article
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- Analysis of convolutional neural networks for fronto-temporal dementia biomarker discovery.International journal of computer assisted radiology and surgery · 2024Article
- The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials.Frontiers in aging neuroscience · 2024Article
- Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations.Acta neuropathologica communications · 2023Article
- Dissecting the Many Faces of Frontotemporal Dementia: An Imaging Perspective.International journal of molecular sciences · 2022Review
- Data-driven staging of genetic frontotemporal dementia using multi-modal MRI.Human brain mapping · 2022Article
- White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretation.Brain and behavior · 2022Article
- Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia.eLife · 2022Article
- Frontotemporal dementia: A unique window on the functional role of the temporal lobes.Handbook of clinical neurology · 2022Review
- Anhedonia in Semantic Dementia-Exploring Right Hemispheric Contributions to the Loss of Pleasure.Brain sciences · 2021Article
- Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia.Neurobiology of aging · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frontotemporal dementia is a degenerative brain condition characterized by focal atrophy affecting the frontal and temporal lobes predominantly. Changes in white matter with disease progression and their relationship to grey matter atrophy remain unknown in FTD. This study aimed to establish longitudinal white matter changes and compare these changes to regional grey matter atrophy in the main FTD subtypes. Diffusion and T₁-weighted images were collected from behavioral-variant FTD (bvFTD: 12), progressive non-fluent aphasia (PNFA: 10), semantic dementia (SD: 11), and 15 controls at baseline and 12 months apart. Changes in white matter integrity were established by fractional anisotropy, mean, axial and radial diffusivity measurements using tract-based spatial statistics. Patterns of cortical grey matter atrophy were measured using voxel-based morphometry. At baseline, bvFTD showed severe cross-sectional changes in orbitofrontal and anterior temporal tracts, which progressed to involve posterior temporal and occipital white matter over the 12-month. In PNFA, cross-sectional changes occurred bilaterally in frontotemporal white matter (left > right), with longitudinal changes more prominent on the right. Initial white matter changes in SD were circumscribed to the left temporal lobe, with longitudinal changes extending to bilateral frontotemporal tracts. In contrast, progression of grey matter change over time was less pronounced in all FTD subtypes. Mean diffusivity was most sensitive in detecting baseline changes while fractional anisotropy and radial diffusivity revealed greatest changes over time, possibly reflecting different underlying pathological processes with disease progression. Our results indicate that investigations of white matter changes reveal important differences across FTD syndromes with disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.