ArticleBioMed research international2014
Immunopathological aspects of experimental Trypanosoma cruzi reinfections.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Intestinal immunopathological evaluation of mice reinfected with Trypanosoma cruzi Y strain.PLoS neglected tropical diseases · 2025Article
- Amiodarone and Ravuconazole Combination Potentiates Chemotherapy against Drug-Resistant Trypanosoma cruzi Strains.ACS omega · 2025Article
- High infection prevalences by Trypanosoma minasense in non-human primates from the Southeast region of Brazil.Scientific reports · 2024Article
- New insights intoFrontiers in immunology · 2024Review
- Chronic Chagas Disease-the Potential Role of Reinfections in Cardiomyopathy Pathogenesis.Current heart failure reports · 2022Review
- The Colombian Strain ofMediators of inflammation · 2022Article
- Interleukin-32Journal of immunology research · 2022Article
- Article
- Correlation between intestinal BMP2, IFNγ, and neural death in experimental infection with Trypanosoma cruzi.PloS one · 2021Article
- Anti-neutrophil cytoplasmic antibody-positive vasculitis presenting with periaortitis and muscle vasculitis in a patient with chronic Chagas disease: comment on the letter by Garcia-Bustos et al.Scandinavian journal of rheumatology · 2020Article
- T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment.Infection and immunity · 2019Article
- Upregulation of Cardiac IL-10 and Downregulation of IFN-Mediators of inflammation · 2018Article
- Epidemiological modeling of Trypanosoma cruzi: Low stercorarian transmission and failure of host adaptive immunity explain the frequency of mixed infections in humans.PLoS computational biology · 2017Article
- Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries.Infectious diseases of poverty · 2015Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chagas disease is caused by Trypanosoma cruzi infection. Besides the host-related factors, such as immune response and genetic background, the parasite, strain, and occurrences of reinfection episodes, may influence disease outcome. Our results demonstrate that both the primary infection and the reinfection with the Colombiana strain are connected with lower survival rate of the mice. After reinfection, parasitaemia is approximately ten times lower than in primary infected animals. Only Colombiana, Colombiana/Colombiana, and Y/Colombiana groups presented amastigote nests in cardiac tissue. Moreover, the mice infected and/or reinfected with the Colombiana strain had more T. cruzi nests, more intense inflammatory infiltrate, and higher in situ expression of TNF-α and IFN-γ than Y strain. Antigen-stimulated spleen cells from infected and/or reinfected animals produced higher levels of TNF-α, IFN-γ, and IL-10. Our results reinforce the idea that Chagas disease outcome is influenced by the strain of the infective parasite, being differentially modulated during reinfection episodes. It highlights the need of control strategies involving parasite strain characterization in endemic areas for Chagas disease.
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