ArticleAvicenna journal of phytomedicine2014
Relaxant effect of Humulus lupulus extracts on isotonic rat's ileum contractions.
Article in Avicenna journal of phytomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Anticholinesterase Activity and Bioactive Compound Profiling of Six Hop (Foods (Basel, Switzerland) · 2024Article
- Supportive therapy for dysmenorrhea: Time to look beyond mefenamic acid in primary care.Journal of family medicine and primary care · 2019Review
- Antispasmodic Activity of Prenylated Phenolic Compounds from the Root Bark ofMolecules (Basel, Switzerland) · 2019Article
- A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions ofInternational journal of veterinary science and medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMany biological studies have been done to determine the activity of medicinal plants on gastrointestinal function. Since acetylcholine is the major transmitter involved in the gastrointestinal motility and there are some evidences regarding the cholinergic modulatory effect of hops extract, in the present study spasmolytic and antispasmodic action of hops (Humulus lupulus) on acetylcholine-induced contraction in isolated rat's ileum was evaluated. MATERIAL AND
methodsIn this study, pieces of isolated rat's ileum were mounted in the internal chamber of an organ bath which was filled with Tyrode's solution and tightly tied to the lever of an isotonic transducer. The contractile responses were recorded by using an oscillograph device. In the presence of normal saline and different concentrations of hops (0.1, 0.3, and 0.5 mg/ml), the amplitude of contractions induced by10(-12) up to 10(-2) M acetylcholine was determined. The spasmolytic action of the same extract concentrations was also examined on contraction induced by 10(-4) acetylcholine.
resultsOur findings indicate that hops extract reduces acetylcholine-induced contraction in all concentrations. The significant inhibitory effects of 0.1, 0.3, and 0.5 mg/ml hops extract on contraction induced by 10(-3) M acetylcholine were 81.9, 77, and 29.3, respectively (p<0.05).
conclusionAccording to our findings, hops extract poses a potent spasmolytic and antispasmodic action on acetylcholine-induced contraction in isolated rat's ileum which may be mediated by cholinergic systems.
Indexed as
Identifiers
25050301PMC4103727W2139146239What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.