ArticleAvicenna journal of phytomedicine2013
Histological, ultrastructural and biochemical studies on the kidney of mice treated with Carthamus tinctorius L. extract.
Article in Avicenna journal of phytomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCarthamus tinctorius L. (C. tinctorius) is used as a food additive but also has medicinal applications. The present work was designed to investigate its probable side effects on the histology and function of the kidney in the mice. MATERIALS AND
methodsSixty adult Balb/C mice were randomly distributed into one control and three experimental groups. The control group received only distilled water, while experimental groups were administered intraperitoneally C. tinctorius at doses of 0.7, 1.4, and 2.8 mg/kg for 49 consecutive days. In the end of experiments after blood sampling, the biochemical analyses of plasma were performed. Tissue samples were also taken and structural alterations were examined using light and electron microscopes.
resultsThere were histological changes included decreasing in the diameter of glomerules, increase of proximal tubular lumen, tubular necrosis, leuckocyte infiltration, and massive congestion in the kidney of the 1.4 and 2.8 mg/kg C. tinctorius groups. Moreover, ultrastructural study revealed destruction of the glomerular basement membrane, shrinkage of podocyte΄s nucleus, and reduction in the number and size of microvilli in epithelial cells of renal tubules. Furthermore, the levels of creatinine in the plasma of 1.4 and 2.8 mg/kg C. tinctorius groups showed a significant increase in comparison with the control group (p<0.05).
conclusionIt is concluded that C. tinctorius extract exposure at doses of 1.4 and 2.8 mg/kg has harmful effects on the renal tissue and therefore, popular consumption of this plant should be reconsidered.
Indexed as
Identifiers
25050283PMC4075719W2108923368What OpenQuestion holds
Registered trials
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