ArticleAvicenna journal of phytomedicine2013
Effect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs.
Article in Avicenna journal of phytomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The impact of Rosa dmascena Mill. on gastrointestinal disorders: a comprehensive analysis through clinical trials, systematic review, and meta-analysis.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025Pooled it
- Effects of Rosa damascena and its compounds on smooth muscle contractility.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2026Review
- Ca' Granda,Molecules (Basel, Switzerland) · 2021Article
- Anti-stress effects of the hydroalcoholic extract ofHeliyon · 2019Article
- Preventive Effect of Hydroalcoholic Extract ofInternational journal of preventive medicine · 2018Article
- Antilisterial Effect ofBioMed research international · 2018Article
- Types of nasal delivery drugs and medications in Iranian traditional medicine to treatment of headache.Iranian Red Crescent medical journal · 2014Review
- Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Effect of hydro-alcoholic extract of Rosa damascena on cardiovascular responses in normotensive rat.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe use of drugs with herbal origin is increasing for treatment of gastrointestinal (GI) disorders. Rosa damascena (R. damascena) is a well-known plant suggested to have beneficial effect on GI system. In this study, the effect of aqueous fraction of R. damascena on the contractions of isolated guinea pig ileum was investigated. MATERIALS AND
methodsAqueous fraction of plant was obtained from ethanolic extract after ethyl acetate and n-butanol fractions were discarded. To evaluate effect of this fraction on ileum contraction, guinea pig ileum was removed and mounted on organ bath and its contraction was recorded. Effect of various concentrations (0.66, 0.83, and 1.3 mg/ml) of aqueous fraction on ileum contraction in comparison with Ach in presence and absence of atropine, a muscarinic antagonist of cholinergic, was evaluated. The response of ileum to 1 µg/ml of acetylcholine was considered as 100% response.
resultsOur results showed that aqueous fractions of R. damascena dose-dependently increased basal guinea pigs ileum contractions (p<0.05 to p<0.001). Maximal contraction of fraction (1.3 mg/ml) induced 23.4 % of maximal Ach response. The contraction of ileum to aqueous fraction was significant decreased in presence 0.001 µg/ml of atropine.
conclusionIt is concluded that aqueous fraction of R. damascena has mild excitatory effect on ileum contraction and this fraction may be beneficial as a mild laxative agent.
Indexed as
Identifiers
25050281PMC4075714W2157042130What OpenQuestion holds
Registered trials
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