ArticleAvicenna journal of phytomedicine2013
Effects of Carthamus tinctorius L. on the ovarian histomorphology and the female reproductive hormones in mice.
Article in Avicenna journal of phytomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Medical uses ofElectronic physician · 2018Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCarthamus tinctorius L. (Safflower) is a member of the asteraceae family which had been classified as a fertility regulator in the traditional medicine. The purpose of this study was to investigate its possible effects on the ovarian histomorphology and the levels of female reproductive hormones in the mice. MATERIALS AND
methodsSixty adult female Balb/C mice were selected and randomly divided into one control and three experimental groups (n= 15). The control group received only distilled water, while experimental groups were administered intraperitoneally C. tinctorius extract at doses of 0.7, 1.4, and 2.8 mg/kg/day for 49 consecutive days. In the end of experiments, blood samples were collected and the sera were analyzed for the levels of FSH, LH, estrogen, and progesterone. Ovarian tissue samples were also taken and histomorphological changes of the ovaries were examined using optical microscope. The quantitative results were statistically analyzed by one-way ANOVA test.
resultsThe present findings showed that treatment with different concentrations of C. tinctorius extract reduced the number of ovarian follicles but number of atretic follicles showed an increase. The number and size of the corpora lutea were not affected by extract administration. In addition, in the treated mice with C. tinctorius extract, the thickness of the tunica albuginea was increased but the relative and absolute weights of the ovaries decreased significantly. Furthermore, the blood levels of the FSH and estrogen were decreased in the three experimental groups compared with those of the control animals.
conclusionThe present findings indicated that treatment with C. tinctorius extract has detrimental effects on the ovarian histomorphology and female reproductive hormones therefore popular consumption of this plant should be reconsidered.
Indexed as
Identifiers
25050271PMC4075700W2169560297What OpenQuestion holds
Registered trials
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