ArticleAvicenna journal of phytomedicine2013
Effects of Foeniculum vulgare ethanol extract on osteogenesis in human mecenchymal stem cells.
Article in Avicenna journal of phytomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Plant-Based Care and Therapy in Ophthalmology.Antioxidants (Basel, Switzerland) · 2025Review
- A Hydrogel Scaffold Incorporating Fennel Seed Extract Induces Osteogenic Differentiation in Mesenchymal Stem Cells.Veterinary medicine and science · 2025Article
- Article
- The potential of plant extracts in cell therapy.Stem cell research & therapy · 2022Review
- Therapeutic Potential of Skin Stem Cells and Cells of Skin Origin: Effects of Botanical Drugs Derived from Traditional Medicine.Stem cell reviews and reports · 2022Review
- Article
- Hydroalcoholic extract and seed of Foeniculum vulgare improve folliculogenesis and total antioxidant capacity level in F1 female mice offspring.BMC complementary medicine and therapies · 2020Article
- Ethnomedicinal Uses of Plant Resources in the Machhapuchchhre Rural Municipality of Kaski District, Nepal.Medicines (Basel, Switzerland) · 2019Article
- A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation.Stem cells international · 2019Review
- Effect of Fennel on the Health Status of Menopausal Women: A Systematic and Meta-analysis.Journal of menopausal medicine · 2018Article
- The Effect of Short-term Treatment with Fennel on Bone Density in Postmenopausal Women: A Randomized Controlled Trial.Journal of menopausal medicine · 2017Article
- Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells.Stem cell research & therapy · 2016Review
- Indian traditional medicinal plants in ophthalmic diseases.Avicenna journal of phytomedicineReview
- Effect of turmeric extract on bone healing in an experimental model of femoral bone fracture.Avicenna journal of phytomedicineArticle
- The Association Between Fennel Extract, Serum Lipid Profile, and Leptin Receptor Expression.Basic and clinical neuroscienceArticle
- Mesenchymal stem cells as a platform for research on traditional medicine.Journal of Ayurveda and integrative medicineReview
- Osteogenic induction of menstrual blood mesenchymal stem cell by differentAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOsteoporosis or silent disease is a major bone disorder in elderly women in current century. Estrogen has an important role in osteogenesis and prevention of bone fractures. Hormone replacement therapy (HRT) is usually accompanied by such effects as breast and ovary cancers. Thus, there is an increasing demand for replacement with plant phytoestrogens. This study is focused on determining the effects of Foeniculum vulgare extract on proliferation and osteogenesis progress in human mesenchymal stem cells. MATERIALS AND
methodsHuman mesenchymal stem cells were isolated and treated with different amount of plant extracts (0.5 to 100 µg/ml). Extract cytotoxicity was measured using MTT assay. The alkaline phosphatase enzyme activity was measured to evaluate the differentiation progress.
resultsRESULTS of MTT assay and alkaline phosphatase activity showed that Foeniculum vulgare extract, at range of 5 to 50 µg/ml, may positively affect cell proliferation and mineralization. The most proliferation and enzyme activity were seen with dose of 5 µg/ml.
conclusionsFoeniculum vulgare has been used in Iranian folk medicine for many years. Our in vitro study showed that Foeniculum vulgare extract has osteoprotective effects.
Indexed as
Identifiers
25050267PMC4075705W2152424467What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.