ArticleInternational journal of nanomedicine2014
Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 107 citations in OpenAlex.
- Controlled drug release and electroconductive performance of 3D printed scaffolds for neural tissue regeneration.Journal of materials science. Materials in medicine · 2026Article
- Beyond Reinforcement: Collagen-Inorganic Composites as a Roadmap for Next-Generation Biomaterials.ACS materials Au · 2026Review
- Evaluation of poly-ε-caprolactone/graphene oxide three-dimensional porous scaffolds for potential application in alveolar bone repair.Journal of dental sciences · 2026Article
- Research on the impact of graphene oxide in feed on growth and health parameters in calves.Frontiers in toxicology · 2025Article
- Guiding Cell Growth: Graphene-Patterned Polymeric Substrates for Enhanced Tissue Proliferation.Nanotechnology, science and applications · 2025Article
- Graphene and its hybrid nanocomposite: A Metamorphoses elevation in the field of tissue engineering.Heliyon · 2024Review
- Applications of Graphene Family Nanomaterials in Regenerative Medicine: Recent Advances, Challenges, and Future Perspectives.International journal of nanomedicine · 2024Review
- Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties.Bioactive materials · 2023Article
- Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application.Biomaterials research · 2023Article
- Application of Graphene Oxide in Oral Surgery: A Systematic Review.Materials (Basel, Switzerland) · 2023Review
- Three-Dimensionally Printed Hydrogel Cardiac Patch for Infarct Regeneration Based on Natural Polysaccharides.Polymers · 2023Article
- Graphene-Based Materials in Dental Applications: Antibacterial, Biocompatible, and Bone Regenerative Properties.International journal of biomaterials · 2023Review
- Fabrication and characterization of PHEMA-gelatin scaffold enriched with graphene oxide for bone tissue engineering.Journal of orthopaedic surgery and research · 2022Article
- Development of Graphene-Based Materials in Bone Tissue Engineaering.Global challenges (Hoboken, NJ) · 2022Review
- Potential of Carbon-Based Nanocomposites for Dental Tissue Engineering and Regeneration.Materials (Basel, Switzerland) · 2021Review
- Biomimetic reduced graphene oxide coated collagen scaffold for in situ bone regeneration.Scientific reports · 2021Article
- Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillers.ACS applied polymer materials · 2021Article
- Multi-Component Hydrogel Beads Incorporated with Reduced Graphene Oxide for pH-Responsive and Controlled Co-Delivery of Multiple Agents.Pharmaceutics · 2021Article
- Graphene and its Derivatives for Bone Tissue Engineering:Frontiers in bioengineering and biotechnology · 2021Review
- Preliminary In Vitro Evaluation of Chitosan-Graphene Oxide Scaffolds on Osteoblastic Adhesion, Proliferation, and Early Differentiation.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGraphene oxide (GO) is a single layer carbon sheet with a thickness of less than 1 nm. GO has good dispersibility due to surface modifications with numerous functional groups. Reduced graphene oxide (RGO) is produced via the reduction of GO, and has lower dispersibility. We examined the bioactivity of GO and RGO films, and collagen scaffolds coated with GO and RGO.
methodsGO and RGO films were fabricated on a culture dish. Some GO films were chemically reduced using either ascorbic acid or sodium hydrosulfite solution, resulting in preparation of RGO films. The biological properties of each film were evaluated by scanning electron microscopy (SEM), atomic force microscopy, calcium adsorption tests, and MC3T3-E1 cell seeding. Subsequently, GO- and RGO-coated collagen scaffolds were prepared and characterized by SEM and compression tests. Each scaffold was implanted into subcutaneous tissue on the backs of rats. Measurements of DNA content and cell ingrowth areas of implanted scaffolds were performed 10 days post-surgery.
resultsThe results show that GO and RGO possess different biological properties. Calcium adsorption and alkaline phosphatase activity were strongly enhanced by RGO, suggesting that RGO is effective for osteogenic differentiation. SEM showed that RGO-modified collagen scaffolds have rough, irregular surfaces. The compressive strengths of GO- and RGO-coated scaffolds were approximately 1.7-fold and 2.7-fold greater, respectively, when compared with the non-coated scaffold. Tissue ingrowth rate was 39% in RGO-coated scaffolds, as compared to 20% in the GO-coated scaffold and 16% in the non-coated scaffold.
conclusionIn summary, these results suggest that GO and RGO coatings provide different biological properties to collagen scaffolds, and that RGO-coated scaffolds are more bioactive than GO-coated scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.