ArticleAsian-Australasian journal of animal sciences2013
Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds.
Article in Asian-Australasian journal of animal sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic Mapping and Diversity of Indigenous and Exotic Rabbits: Adaptive and Conservation Strategies.Genes · 2025Article
- Genetic assessment of litter size, body weight, carcass traits and gene expression profiles in exotic and indigenous rabbit breeds: a study on New Zealand White, Californian, and Gabali rabbits in Egypt.Tropical animal health and production · 2024Article
- Association of the single nucleotide polymorphism in CAPN3 gene with growth performance in Merino and Garut (MEGA) backcross sheep.Journal, genetic engineering & biotechnology · 2023Article
- Influence of polymorphisms in candidate genes on carcass and meat quality traits in rabbits.PloS one · 2023Article
- Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis.Communications biology · 2022Article
- TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.Scientific reports · 2020Article
- Hybrid Versus Autochthonous Turkey Populations: Homozygous Genomic Regions Occurrences Due to Artificial and Natural Selection.Animals : an open access journal from MDPI · 2020Article
- Whole genome re-sequencing reveals recent signatures of selection in three strains of farmed Nile tilapia (Oreochromis niloticus).Scientific reports · 2020Article
- A Genome-Wide Association Study Identifying Genetic Variants Associated with Growth, Carcass and Meat Quality Traits in Rabbits.Animals : an open access journal from MDPI · 2020Article
- Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.The Biochemical journal · 2018Article
- Tbc1d1 deletion suppresses obesity in leptin-deficient mice.International journal of obesity (2005) · 2016Article
- Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice.American journal of physiology. Endocrinology and metabolism · 2016Article
- Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice.American journal of physiology. Endocrinology and metabolism · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TBC1D1 plays a key role in body energy homeostasis by regulating the insulin-stimulated glucose uptake in skeletal muscle. The present study aimed to identify the association between genetic polymorphisms of TBC1D1 and body weight (BW) in rabbits. Among the total of 12 SNPs detected in all 20 exons, only one SNP was non-synonymous (c.214G>A. p.G72R) located in exon 1. c.214G>A was subsequently genotyped among 491 individuals from two rabbit breeds by the high-resolution melting method. Allele A was the predominant allele with frequencies of 0.7780 and 0.6678 in European white rabbit (EWR, n = 205) and New Zealand White rabbit (NZW, n = 286), respectively. The moderate polymorphism information content (0.25<PIC<0.50) was present in both breeds. The association analysis revealed that genotypes GA and AA had higher 35 d body weight (BW) than genotype GG in both EWR (p<0.01) and NEW (p<0.05). For the 56 d BW and 70 d BW traits, genotypes AA and GA were higher than genotype GG in both two breeds, the difference was not significant (p>0.05). Our results implied that the c.214G>A of TBC1D1 gene might be one of the candidate loci affecting the trait of 35 d BW in the rabbit.
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