ArticleAsian-Australasian journal of animal sciences2013
Effect of FTO Expression and Polymorphism on Fat Deposition in Suzhong Pigs.
Article in Asian-Australasian journal of animal sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of magnesium potassium sulfate on Tibetan sheep quality and its volatile and non-volatile metabolic substances.Frontiers in nutrition · 2026Article
- Association Analysis of theAnimals : an open access journal from MDPI · 2025Article
- Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages.Scientific reports · 2024Article
- Isolation and ex vivo cultivation of single myofibers from porcine muscle.In vitro cellular & developmental biology. Animal · 2020Article
- Excessive BCAA regulates fat metabolism partially through the modification of mNutrition & metabolism · 2020Article
- The FTO Gene Is Associated with Growth and Omega-3/-6 Ratio in Asian Seabass.Marine biotechnology (New York, N.Y.) · 2018Article
- Tissue Distribution of Porcine FTO and Its Effect on Porcine Intramuscular Preadipocytes Proliferation and Differentiation.PloS one · 2016Article
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3 authors at 1 institution in 1 country.
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Abstract
Fat mass and obesity associated gene (FTO) plays an important role in appetite control and energy consumption in human and mice. In order to examine FTO expression influence on fat deposition in Suzhong pigs, FTO mRNA expression was detected in 16 tissues by RT-PCR, FTO protein expression was detected in 5 tissues by western blot, and association of FTO polymorphism with meat quality traits was analyzed in Suzhong populations with 714 records. RT-PCR results revealed that FTO mRNA was expressed in all sixteen tissues with significant differences (p<0.05), expression in backfat was significantly higher than that of any other tissue (p<0.05), and expression in longissimus dorsi muscle had the second highest significance level (p<0.05). Western blot results demonstrated that FTO protein was highly expressed in backfat and longissimus dorsi muscle. Furthermore, FTO mRNA and protein expression in tissues of high-fat pigs was significantly higher than that of low-fat pigs (p<0.05), suggesting FTO expression had advantageous effects on fat deposition. FTO polymorphism results evidenced that at A227G locus, G allele seemed to have advantageous effects on fat deposition, indicating it could be a significant candidate gene for improving pork quality in Suzhong pigs.
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