ArticleAsian-Australasian journal of animal sciences2012
Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks.
Article in Asian-Australasian journal of animal sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Photostimulation increases food intake, agouti-related protein (AGRP) and type II iodothyronine deiodinase (DIO2) gene expression in the medio-basal hypothalamus of Gambel's White-crowned Sparrow.Journal of neuroendocrinology · 2025Article
- A bird's-eye overview of molecular mechanisms regulating feed intake in chickens-with mammalian comparisons.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Dietary restriction in senolysis and prevention and treatment of disease.Critical reviews in food science and nutrition · 2024Review
- Effects of time-restricted eating with different eating duration on anthropometrics and cardiometabolic health: A systematic review and meta-analysis.World journal of cardiology · 2023Article
- Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry.Animals : an open access journal from MDPI · 2020Review
- Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens.Frontiers in physiology · 2020Review
- Sex differences in basal hypothalamic anorectic and orexigenic gene expression and the effect of quantitative and qualitative food restriction.Biology of sex differences · 2018Article
- The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus).Scientific reports · 2017Article
- The role of cinnamon as a modulator of the expression of genes related to antioxidant activity and lipid metabolism of laying quails.PloS one · 2017Article
- Regulation of Agouti-Related Protein and Pro-Opiomelanocortin Gene Expression in the Avian Arcuate Nucleus.Frontiers in endocrinology · 2017Review
- Hypothalamic AMPK as a Regulator of Energy Homeostasis.Neural plasticity · 2016Review
- Effect of dexamethasone on hypothalamic expression of appetite-related genes in chickens under different diet and feeding conditions.Journal of animal science and biotechnology · 2016Article
- Methionine Supplementation of Maternal Diet Improves Hatching Traits, Initial Development, and Performance in Japanese Quail Fed Different Levels of Methionine During Growth.Animal science journal = Nihon chikusan GakkaihoArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 5'-adenosine monophosphate-activated protein kinase (AMPK) is a key part of a kinase-signaling cascade that acts to maintain energy homeostasis. The objective of this experiment was to investigate the possible effects of fasting and refeeding on the gene expression of hypothalamic AMPK, some appetitive regulating peptides and lipid metabolism related enzymes. Seven-day-old male broiler (Arbor Acres) chicks were allocated into three equal treatments: fed ad libitum (control); fasted for 24 h; fasted for 24 h and then refed for 24 h. Compared with the control, the hypothalamic gene expression of AMPKα2, AMPKβ1, AMPKβ2, AMPKγ1, Ste20-related adaptor protein β (STRADβ), mouse protein 25α (MO25α) and agouti-related peptide (AgRP) were increased after fasting for 24 h. No significant difference among treatments was observed in mRNA levels of AMPKα1, AMPKγ2, LKB1 and neuropeptide Y (NPY). However, the expression of MO25β, pro-opiomelanocortin (POMC), corticotropin-releasing hormone (CRH), ghrelin, fatty acid synthase (FAS), acetyl-CoA carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT-1) and sterol regulatory element binding protein-1 (SREBP-1) were significantly decreased. The present results indicated that 24 h fasting altered gene expression of AMPK subunits, appetite regulation peptides and lipometabolism related factors in chick's hypothalamus; the hypothalamic FAS signaling pathway might be involved in the AMPK regulated energy homeostasis and/or appetite regulation in poultry.
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