Trial reportProceedings of the National Academy of Sciences of the United States of America2014
A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 6 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Systematic review of family-based interventions integrating cultural and family resilience components to improve Black adolescent health outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Pooled it
- Physiological Effects of Psychological Interventions Among Persons with Financial Stress: A Systematic Review, Meta-analysis, and Introduction to Psychophysiological Economics.Applied psychophysiology and biofeedback · 2024Pooled it
- The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review.Child psychiatry and human development · 2023Pooled it
- Adverse Childhood Experiences and Blood Pressure in Women in the United States: A Systematic Review.Journal of midwifery & women's health · 2021Pooled it
- Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.JAMA psychiatry · 2020Pooled it
- Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018Pooled it
- Inflammatory markers in serum and placenta in a randomized controlled trial of group prenatal care.American journal of obstetrics & gynecology MFM · 2023Trial
- A perinatal coparenting intervention: Effects of a randomized trial on parent cardiometabolic risk and self-reported health.Biological psychology · 2023Trial
- A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation.Child development · 2019Trial
- Unsupportive parenting moderates the effects of family psychosocial intervention on metabolic syndrome in African American youth.International journal of obesity (2005) · 2018Trial
- Annual Research Review: Beyond the target - understanding crossover effects in family-centered prevention.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- DNA methylation in the placenta and household socioeconomic status: the SPAH study.Clinical epigenetics · 2026Article
- Transdiagnostic prevention in youth mental health, Part II: interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Parenting Stress, Parental Self-Efficacy, and Coparenting: Prospective Associations with Child Metabolic Health.Journal of child and family studies · 2026Article
- Allostatic load profiles, resilience, and psychosocial adaptation in young adults.Frontiers in psychology · 2026Article
- Discrimination, psychosocial resources, and sleep: A test of the reserve capacity model.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Associations of multiple dimensions of socioeconomic status with adverse pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- Childhood Adversity and Cardiovascular Disease; Current Knowledge and Future Directions.Current cardiology reports · 2025Review
- Providing Buffers, Solving Barriers: Value-Driven Policies and Actions that Protect Clients Today and Increase the Chances of Thriving Tomorrow.Behavior analysis in practice · 2025Article
- Childhood exposure to danger increases Black youths' alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis.Development and psychopathology · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Children of low socioeconomic status (SES) are at elevated risk for health problems across the lifespan. Observational studies suggest that nurturant parenting might offset some of these health risks, but their design precludes inferences about causal direction and clinical utility. Here we ask whether a psychosocial intervention, focused improving parenting, strengthening family relationships, and building youth competencies, can reduce inflammation in low-SES, African Americans from the rural South. The trial involved 272 mothers and their 11-y-old children from rural Georgia, half of whose annual household incomes were below the federal poverty line. Families were randomly assigned to a 7-wk psychosocial intervention or to a control condition. When youth reached age 19, peripheral blood was collected to quantify six cytokines that orchestrate inflammation, the dysregulation of which contributes to many of the health problems known to pattern by SES. Youth who participated in the intervention had significantly less inflammation on all six indicators relative to controls (all P values < 0.001; effect sizes in Cohen's d units ranged from -0.69 to -0.91). Mediation analyses suggested that improved parenting was partially responsible for the intervention's benefits. Inflammation was lowest among youth who received more nurturant-involved parenting, and less harsh-inconsistent parenting, as a consequence of the intervention. These findings have theoretical implications for research on resilience to adversity and the early origins of disease. If substantiated, they may also highlight a strategy for practitioners and policymakers to use in ameliorating social and racial health disparities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.