ArticleProceedings of the National Academy of Sciences of the United States of America2014
Complete genome of a nonphotosynthetic cyanobacterium in a diatom reveals recent adaptations to an intracellular lifestyle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 143 citations in OpenAlex.
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- Network Component Analysis Can Identify Potential Axenisation Strategies Circumventing Antibiotic-Use for Phototrophic Eukaryotic Microalgae.Environmental microbiology reports · 2026Review
- Symbiotic N-Fixing Bacteria in the Root and Leaf of Typical Alpine Grassland Plants.Microbial ecology · 2025Article
- Ecosystem consequences of a nitrogen-fixing proto-organelle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome analysis of dark-adapted variants identifies the phosphatase gene phsP involved in the regulation of photosynthetic and dark-heterotrophic growth in the cyanobacterium Leptolyngbya boryana.Plant & cell physiology · 2025Article
- Selection Maintains Photosynthesis in a Symbiotic Cyanobacterium Despite Redundancy With its Fern Host.Molecular biology and evolution · 2025Article
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- Novel pennate diatom symbionts support high NISME communications · 2025Article
- Diurnal transcriptional variation is reduced in a nitrogen-fixing diatom endosymbiont.The ISME journal · 2024Article
- The genome sequences of the marine diatomWellcome open research · 2024Article
- The endosymbiont ofISME communications · 2024Article
- Heterologous expression of genes from a cyanobacterial endosymbiont highlights substrate exchanges with its diatom host.PNAS nexus · 2023Article
- A robust approach to estimate relative phytoplankton cell abundances from metagenomes.Molecular ecology resources · 2023Article
- Article
- Zam Is a Redox-Regulated Member of the RNB-Family Required for Optimal Photosynthesis in Cyanobacteria.Microorganisms · 2022Article
- Overlooked and widespread pennate diatom-diazotroph symbioses in the sea.Nature communications · 2022Article
- Organellar Evolution: A Path from Benefit to Dependence.Microorganisms · 2022Review
- Evolutionary genomic insights into cyanobacterial symbioses in plants.Quantitative plant biology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of mitochondria and plastids from bacterial endosymbionts were key events in the origin and diversification of eukaryotic cells. Although the ancient nature of these organelles makes it difficult to understand the earliest events that led to their establishment, the study of eukaryotic cells with recently evolved obligate endosymbiotic bacteria has the potential to provide important insight into the transformation of endosymbionts into organelles. Diatoms belonging to the family Rhopalodiaceae and their endosymbionts of cyanobacterial origin (i.e., "spheroid bodies") are emerging as a useful model system in this regard. The spheroid bodies, which appear to enable rhopalodiacean diatoms to use gaseous nitrogen, became established after the divergence of extant diatom families. Here we report what is, to our knowledge, the first complete genome sequence of a spheroid body, that of the rhopalodiacean diatom Epithemia turgida. The E. turgida spheroid body (EtSB) genome was found to possess a gene set for nitrogen fixation, as anticipated, but is reduced in size and gene repertoire compared with the genomes of their closest known free-living relatives. The presence of numerous pseudogenes in the EtSB genome suggests that genome reduction is ongoing. Most strikingly, our genomic data convincingly show that the EtSB has lost photosynthetic ability and is metabolically dependent on its host cell, unprecedented characteristics among cyanobacteria, and cyanobacterial symbionts. The diatom-spheroid body endosymbiosis is thus a unique system for investigating the processes underlying the integration of a bacterial endosymbiont into eukaryotic cells.
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