ArticleThe Journal of cell biology2014
Klar ensures thermal robustness of oskar localization by restraining RNP motility.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Monitoring fatty acid trafficking duringbioRxiv : the preprint server for biology · 2026Article
- An architectural role of specific RNA-RNA interactions in oskar granules.Nature cell biology · 2024Article
- Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis.PLoS genetics · 2023Article
- An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport.The Journal of cell biology · 2023Article
- Article
- Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.Genes & development · 2021Article
- Motility Plays an Important Role in the Lifetime of Mammalian Lipid Droplets.International journal of molecular sciences · 2021Review
- Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis.Developmental cell · 2019Article
- Live cell imaging reveals 3'-UTR dependent mRNA sorting to synapses.Nature communications · 2019Article
- The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo.Nature communications · 2019Article
- Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.Nature communications · 2019Article
- Enzymatic production of single-molecule FISH and RNA capture probes.RNA (New York, N.Y.) · 2017Article
- Article
- An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs.The EMBO journal · 2017Article
- Drosophila KASH-domain protein Klarsicht regulates microtubule stability and integrin receptor localization during collective cell migration.Developmental biology · 2015Article
- As the fat flies: The dynamic lipid droplets of Drosophila embryos.Biochimica et biophysica acta · 2015Review
- Lipid droplet motility and organelle contacts.Contact (Thousand Oaks (Ventura County, Calif.))Article
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Authors and funding
6 authors.
Funding
Abstract
Communication usually applies feedback loop-based filters and amplifiers to ensure undistorted delivery of messages. Such an amplifier acts during Drosophila melanogaster midoogenesis, when oskar messenger ribonucleic acid (mRNA) anchoring depends on its own locally translated protein product. We find that the motor regulator Klar β mediates a gain-control process that prevents saturation-based distortions in this positive feedback loop. We demonstrate that, like oskar mRNA, Klar β localizes to the posterior pole of oocytes in a kinesin-1-dependent manner. By live imaging and semiquantitative fluorescent in situ hybridization, we show that Klar β restrains oskar ribonucleoprotein motility and decreases the posterior-ward translocation of oskar mRNA, thereby adapting the rate of oskar delivery to the output of the anchoring machinery. This negative regulatory effect of Klar is particularly important for overriding temperature-induced changes in motility. We conclude that by preventing defects in oskar anchoring, this mechanism contributes to the developmental robustness of a poikilothermic organism living in a variable temperature environment.
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