ArticlePhysics in medicine and biology2014
Improving PET spatial resolution and detectability for prostate cancer imaging.
Article in Physics in medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Uncertainty-aware gamma interaction localization and reconstruction in PET.Medical physics · 2026Article
- Article
- The impact of iterative reconstruction protocol, signal-to-background ratio and background activity on measurement of PET spatial resolution.Japanese journal of radiology · 2020Article
- Image quality and detectability in Siemens Biograph PET/MRI and PET/CT systems-a phantom study.EJNMMI physics · 2019Article
- Objective comparison of lesion detectability in low and medium-energy collimator iodine-123 mIBG images using a channelized Hotelling observer.Physics in medicine and biology · 2017Article
- On the assessment of spatial resolution of PET systems with iterative image reconstruction.Physics in medicine and biology · 2016Article
- The use of (18)F-FDG PET to differentiate progressive disease from treatment induced necrosis in high grade glioma.Journal of neuro-oncology · 2015Article
- Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles.International journal of nanomedicine · 2015Article
- State-Of-The-Art and Recent Advances in Quantification for Therapeutic Follow-Up in Oncology Using PET.Frontiers in medicine · 2015Review
- New prospects for PET in prostate cancer imaging: a physicist's viewpoint.EJNMMI physics · 2014Article
- NIR fluorescent small molecules for intraoperative imaging.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
Prostate cancer, one of the most common forms of cancer among men, can benefit from recent improvements in positron emission tomography (PET) technology. In particular, better spatial resolution, lower noise and higher detectability of small lesions could be greatly beneficial for early diagnosis and could provide a strong support for guiding biopsy and surgery. In this article, the impact of improved PET instrumentation with superior spatial resolution and high sensitivity are discussed, together with the latest development in PET technology: resolution recovery and time-of-flight reconstruction. Using simulated cancer lesions, inserted in clinical PET images obtained with conventional protocols, we show that visual identification of the lesions and detectability via numerical observers can already be improved using state of the art PET reconstruction methods. This was achieved using both resolution recovery and time-of-flight reconstruction, and a high resolution image with 2 mm pixel size. Channelized Hotelling numerical observers showed an increase in the area under the LROC curve from 0.52 to 0.58. In addition, a relationship between the simulated input activity and the area under the LROC curve showed that the minimum detectable activity was reduced by more than 23%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.