ArticlePloS one2014
Multiple phenotypic changes associated with large-scale horizontal gene transfer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Dead but Not Forgotten: How Extracellular DNA, Moisture, and Space Modulate the Horizontal Transfer of Extracellular Antibiotic Resistance Genes in Soil.Applied and environmental microbiology · 2022Article
- Experimental evolution of the megaplasmid pMPPla107 inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Introduction: the secret lives of microbial mobile genetic elements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Genomic Background Governs Opposing Responses to Nalidixic Acid upon Megaplasmid Acquisition inmSphere · 2021Article
- Destabilization of the Tumor-Inducing Plasmid from an Octopine-TypeG3 (Bethesda, Md.) · 2019Article
- Just the Two of Us? A Family of Pseudomonas Megaplasmids Offers a Rare Glimpse into the Evolution of Large Mobile Elements.Genome biology and evolution · 2019Article
- Combining sequencing approaches to fully resolve a carbapenemase-encoding megaplasmid in aEmerging microbes & infections · 2019Article
- Assessing the benefits of horizontal gene transfer by laboratory evolution and genome sequencing.BMC evolutionary biology · 2018Article
- Evolution of the Quorum network and the mobilome (plasmids and bacteriophages) in clinical strains of Acinetobacter baumannii during a decade.Scientific reports · 2018Article
- Transmission in the Origins of Bacterial Diversity, From Ecotypes to Phyla.Microbiology spectrum · 2017Article
- Fitness Costs of Plasmids: a Limit to Plasmid Transmission.Microbiology spectrum · 2017Review
- The Divided Bacterial Genome: Structure, Function, and Evolution.Microbiology and molecular biology reviews : MMBR · 2017Review
- Conflicting selection alters the trajectory of molecular evolution in a tripartite bacteria-plasmid-phage interaction.Molecular ecology · 2017Article
- Article
- Plasmid carriage can limit bacteria-phage coevolution.Biology letters · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer often leads to phenotypic changes within recipient organisms independent of any immediate evolutionary benefits. While secondary phenotypic effects of horizontal transfer (i.e., changes in growth rates) have been demonstrated and studied across a variety of systems using relatively small plasmids and phage, little is known about the magnitude or number of such costs after the transfer of larger regions. Here we describe numerous phenotypic changes that occur after a large-scale horizontal transfer event (∼1 Mb megaplasmid) within Pseudomonas stutzeri including sensitization to various stresses as well as changes in bacterial behavior. These results highlight the power of horizontal transfer to shift pleiotropic relationships and cellular networks within bacterial genomes. They also provide an important context for how secondary effects of transfer can bias evolutionary trajectories and interactions between species. Lastly, these results and system provide a foundation to investigate evolutionary consequences in real time as newly acquired regions are ameliorated and integrated into new genomic contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.