ArticleYonsei medical journal2014
Histone acetylation level and histone acetyltransferase/deacetylase activity in ejaculated sperm from normozoospermic men.
Article in Yonsei medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Predictive model of sperm DNA fragmentation in infertile men based on lifestyle factors.Frontiers in endocrinology · 2025Article
- Variation of sperm quality and circular RNA content in men exposed to environmental contamination with heavy metals in 'Land of Fires', Italy.Human reproduction (Oxford, England) · 2024Article
- Article
- Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome.Epigenetics & chromatin · 2022Article
- Effects of illicit drugs on structural and functional impairment of testis, endocrinal disorders, and molecular alterations of the semen.Iranian journal of basic medical sciences · 2021Review
- The possible role of sirtuins in male reproduction.Molecular and cellular biochemistry · 2021Review
- Effects of Morphine on Serum Reproductive Hormone Levels and the Expression of Genes Involved in Fertility-related Pathways in Male Rats.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle.Scientific reports · 2020Article
- Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality.Journal of clinical medicine · 2020Review
- Epigenetic changes in mammalian gametes throughout their lifetime: the four seasons metaphor.Chromosoma · 2019Review
- Lysine acetylation modulates mouse sperm capacitation.Scientific reports · 2018Article
- Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).Molecular & cellular proteomics : MCP · 2015Article
- Low long non-coding RNA HOTAIR expression is associated with down-regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia.International journal of clinical and experimental pathology · 2015Article
- Melatonin ameliorates the adverse effects of leptin on sperm.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
purposeThe aim of this work was to evaluate nuclear histone acetylation level and total histone acetyltransferase (HAT) and deacetylase (HDAC) activity in ejaculated sperm and their relevance to conventional sperm parameters. MATERIALS AND
methodsThirty-three normozoospermic men were included in this study. Semen samples were processed by swim-up and then immunostained by six acetylation antibodies (H3K9ac, H3K14ac, H4K5ac, H4K8ac, H4K12ac, and H4K16ac). Our preliminary study verified the expression of HAT/HDAC1 in mature human sperm. From vitrified-warmed sperm samples, total HAT/HDAC activity was measured by commercially available kits. Nuclear DNA integrity was also measured by TUNEL assay.
resultsThe levels of six acetylation marks were not related with conventional sperm parameters including sperm DNA fragmentation index (DFI) as well as HAT/HDAC activity. However, sperm DFI was positively correlated with HAT activity (r=0.038 after adjustment, p<0.02). HAT activity showed a negative relationship with HDAC activity (r=-0.51, p<0.01). Strict morphology was negatively correlated with acetylation enzyme index (=HAT activity/HDAC activity) (r=-0.53, p<0.01).
conclusionOur works demonstrated a significant relationship of acetylation-associated enzyme activity and strict morphology or sperm DFI.
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