ArticleNature communications2014
Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Article
- Cuproptosis inducers mediate cold lethality via SLCR-46.1 in C. elegans.Nature communications · 2026Article
- Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans.Nature neuroscience · 2026Article
- Freezing forgetting in C. elegans to extend memory retention.Nature neuroscience · 2026Article
- Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the NematodeCells · 2025Review
- Reprograming gene expression in 'hibernating'eLife · 2025Article
- Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Identification and Transcriptome Analysis ofInternational journal of molecular sciences · 2024Article
- The intron binding protein EMB-4 is an opposite regulator of cold and high temperature tolerance inPNAS nexus · 2024Article
- Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans.Nature communications · 2024Article
- Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B.Scientific reports · 2024Article
- G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans.Nature communications · 2024Article
- Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans.Nature communications · 2024Article
- Cold Tolerance in the Nematode Caenorhabditis elegans.Advances in experimental medicine and biology · 2024Review
- Oxygen is toxic in the cold inFrontiers in physiology · 2024Article
- Role of gustatory neurons opposing TGF-β in regulating nictation behavior inJournal of biosciences · 2024Article
- Cytochrome P450 and Epoxide Hydrolase Metabolites in Aβ and tau-induced Neurodegeneration: Insights frombioRxiv : the preprint server for biology · 2023Article
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.EMBO reports · 2023Article
- Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity.PLoS genetics · 2023Article
- High-throughput submicron-resolution microscopy ofiScience · 2023Article
5 more citing papers are in PubMed but not listed here.
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Temperature is a critical environmental stimulus that has a strong impact on an organism's biochemistry. Animals can respond to changes in ambient temperature through behaviour or altered physiology. However, how animals habituate to temperature is poorly understood. The nematode C. elegans stores temperature experiences and can induce temperature habituation-linked cold tolerance. Here we show that light and pheromone-sensing neurons (ASJ) regulate cold habituation through insulin signalling. Calcium imaging reveals that ASJ neurons respond to temperature. Cold habituation is abnormal in a mutant with impaired cGMP signalling in ASJ neurons. Insulin released from ASJ neurons is received by the intestine and neurons regulating gene expression for cold habituation. Thus, temperature sensation in a light and pheromone-sensing neuron produces a robust effect on insulin signalling that controls experience-dependent temperature habituation.
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