ArticleMolecular biology reports2014
Melanocortin-4 receptor (MC4R) polymorphisms are associated with growth and meat quality traits in sheep.
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Computational analysis of non-synonymous SNPs in the sheep MC4R gene.Journal, genetic engineering & biotechnology · 2026Article
- A conserved functional missense SNP (E100K) in sheep MC4R gene leading to functional loss and impacting the growth traits.Journal of animal science · 2026Article
- Molecular markers associated with growth, meat, and carcass traits in sheep: a review.Animal biotechnology · 2025Review
- Rapid SNP genotyping detection method based on PCR-lateral flow dipstick detection technique.Scientific reports · 2025Article
- A Critical Functional Missense Mutation (T117M) in SheepAnimals : an open access journal from MDPI · 2024Article
- Association of the MC4R gene with growth traits and meat quality in Colombian hair sheep.Journal of advanced veterinary and animal research · 2023Article
- Two co-inherited novel SNPs in the MC4R gene related to live body weight and hormonal assays in Awassi and Arabi sheep breeds of Iraq.Veterinary medicine and science · 2021Article
- Variation in the Promoter Region of theInternational journal of molecular sciences · 2019Article
- The distribution of runs of homozygosity and selection signatures in six commercial meat sheep breeds.PloS one · 2017Article
- Identification of MEF2B and TRHDE Gene Polymorphisms Related to Growth Traits in a New Ujumqin Sheep Population.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of melanocortin 4 receptor gene (MC4R) in food intake and body weight regulation is well characterized. MC4R mutations are the most frequent monogenic cause of human obesity. Significant associations have been revealed between MC4R mutations and productive traits in pigs, cattle and poultry. Herein, fluorescence-based conformation sensitive gel electrophoresis was used to identify two single nucleotide polymorphisms (SNPs) in the coding region (93G>A and 292G>A) and two SNPs in the 3'-UTR area (1016G>A and 1240T>C) of MC4R gene in 132 German Merino sheep. We found that the 1016G>A mutation in the 3'-UTR was significantly associated with body weight at 120 and 180 days, average daily gain, back fat thickness and loin-eye area. Allele A located at the 292th position of MC4R gene representing Arg98 was associated with significantly higher loin-eye area in sheep. For the synonymous 93G>A mutation, A allele carrier animals had higher back fat thickness. Our results provide evidence that the MC4R gene may be a candidate gene for growth and meat quality traits with MC4R SNPs being potentially valuable as genetic markers for economic traits in German Merino sheep.
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