Evidence map›Paper›PMID 25048075›Full record

Trial reportEuropean journal of applied physiology2014

Small-sided games training reduces CRP, IL-6 and leptin in sedentary, middle-aged men.

Amy E Mendham, Rob Duffield, Frank Marino, Aaron J Coutts

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Role of C-Reactive Protein, An Inflammatory Biomarker in The Development of Atherosclerosis and Its Treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
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  14. Metabolic and inflammatory health in SARS-CoV-2 and the potential role for habitual exercise in reducing disease severity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amy E MendhamSchool of Human Movement Studies, Charles Sturt University, Panorama Avenue, Bathurst, NSW, 2795, Australia, amendham@csu.edu.au.
Rob Duffield
Frank Marino
Aaron J Coutts
Charles Sturt University · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLong-term physical activity is reported to improve chronic systemic inflammation, which provides protection against the ensuing development of chronic disease. Accordingly, the present study assessed changes in pro- and anti-inflammatory cytokines, aerobic capacity and body composition following 8 weeks of either small-sided games (SSG) or cycling (CYC) training compared to a sedentary control (CON) condition.

methodsThirty-three middle-aged, sedentary men were randomized into CYC (n = 11), SSG (n = 11), or CON (n = 11) conditions. The CYC and SSG conditions trained 3 days/week for 8 weeks, whilst CON maintained habitual activity and dietary patterns. Pre- and post-intervention testing included a dual-energy X-ray absorptiometry scan, sub-maximal (80% maximal heart rate) aerobic capacity (VO₂) and fasting venous blood. Venous blood measures for pro-inflammatory markers included C-reactive protein (CRP), interleukin (IL)-6, IL-1β, tumor necrosis factor-α, and leptin; anti-inflammatory markers included IL-10, IL-1 receptor agonist, and adiponectin.

resultsBoth CYC and SSG increased submaximal power output and VO₂ (P < 0.05), decreased total body fat-mass (TB-FM; P < 0.05), and CRP (SSG, -0.45 ± 0.42 mg L(-1); P = 0.008; CYC, -0.44 ± 0.59 mg L(-1); P = 0.02). Only SSG increased total body fat-free mass (TB-FFM; +1.1 ± 1.2 kg; P = 0.001) and decreased concentration of plasma IL-6 (-0.69 ± 0.62 pg mL(-1); P = 0.002) and leptin (-2,212 ± 2,531 ng mL(-1); P = 0.014).

conclusionCycling and SSG training were both effective at improving CRP, VO₂ and TB-FM. Furthermore, SSG training has also shown to be an effective training approach in reducing IL-6 and leptin and increasing muscle mass within sedentary, middle-aged men.

Indexed as

Resistance TrainingSedentary BehaviorAdultC-Reactive ProteinFootballHeart RateHumansInterleukin-6LeptinMaleMiddle AgedOxygen ConsumptionC-Reactive ProteinInterleukin-6Leptin

Identifiers

PMID25048075
OpenAlexW2035022811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.