ReviewMolecular psychiatry2015
All the world's a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective.
Review in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis.Molecular psychiatry · 2016Pooled it
- Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome.Journal of psychiatric research · 2021Trial
- A Multi-Dimensional and Integrative Approach to Examining the High-Risk and Ultra-High-Risk Stages of Bipolar Disorder.EBioMedicine · 2015Trial
- Unstable sleep and rest-activity rhythms in adolescents at-risk for bipolar disorder: Links to mood symptoms and the effect of sleep stabilization.Journal of affective disorders · 2026Article
- Neuroinflammation and white matter microstructure as mediators of cognitive deficits in offspring of parents with bipolar disorder.Brain communications · 2026Article
- Mood states recognition based on Mandarin speech and deep learning in patients with bipolar disorder.BMC psychiatry · 2025Article
- Where is mania in the meta-structure of psychopathology?Psychological medicine · 2025Article
- A Machine-Learning-Based Analysis of Resting State Electroencephalogram Signals to Identify Latent Schizotypal and Bipolar Development in Healthy University Students.Diagnostics (Basel, Switzerland) · 2025Article
- Challenges in the development of treatment guidelines for bipolar disorder.Frontiers in psychiatry · 2025Article
- Media Use and Its Associations With Paranoia in Schizophrenia and Bipolar Disorder: Ecological Momentary Assessment.JMIR mental health · 2024Article
- Immediate post performance judgements about cognitive performance in schizophrenia and bipolar disorder: associations with test performance and subjective overall judgments regarding abilities.Cognitive neuropsychiatry · 2023Article
- Psychological Testing in a Complex Case: Psychosis in Co-occurring PTSD, Gender Dysphoria, and Bipolar Disorder.Cureus · 2023Article
- Negative mood states as a correlate of cognitive performance and self-assessment of cognitive performance in bipolar disorder versus schizophrenia.Schizophrenia research · 2023Article
- Accuracy of immediate self-assessment of neurocognitive test performance: Associations with psychiatric diagnosis and longitudinal psychotic symptoms.Journal of psychiatric research · 2022Article
- A closer look at avolition in schizophrenia and bipolar disorder: Persistence of different types of activities over time.Schizophrenia research · 2022Article
- Revisiting how People with Schizophrenia Spend Their Days: Associations of lifetime milestone Achievements with Daily Activities examined with Ecological Momentary Assessment.Psychiatry research communications · 2022Article
- Integrity of cerebellar tracts associated with the risk of bipolar disorder.Translational psychiatry · 2022Article
- Stage models for major depression: Cognitive behavior therapy, mechanistic treatment targets, and the prevention of stage transition.Clinical psychology review · 2022Review
- Consensus on nomenclature for clinical staging models in bipolar disorder: A narrative review from the International Society for Bipolar Disorders (ISBD) Staging Task Force.Bipolar disorders · 2021Review
- Symptoms and Characteristics of Youth Hospitalized for Depression: Subthreshold Manic Symptoms Can Help Differentiate Bipolar from Unipolar Depression.Journal of child and adolescent psychopharmacology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Psychiatric disorders have traditionally been classified using a static, categorical approach. However, this approach falls short in facilitating understanding of the development, common comorbid diagnoses, prognosis and treatment of these disorders. We propose a 'staging' model of bipolar disorder that integrates genetic and neural information with mood and activity symptoms to describe how the disease progresses over time. From an early, asymptomatic, but 'at-risk' stage to severe, chronic illness, each stage is described with associated neuroimaging findings as well as strategies for mapping genetic risk factors. Integrating more biologic information relating to cardiovascular and endocrine systems, refining methodology for modeling dimensional approaches to disease and developing outcome measures will all be crucial in examining the validity of this model. Ultimately, this approach should aid in developing targeted interventions for each group that will reduce the significant morbidity and mortality associated with bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.