ArticleOrganic & biomolecular chemistry2014
Demonstration of a common indole-based aromatic core in natural and synthetic eumelanins by solid-state NMR.
Article in Organic & biomolecular chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Microbial production of eumelanin from a desert-derived Aspergillus terreus: statistical optimization, comprehensive characterization, and in silico insights into breast cancer-associated targets.Microbial cell factories · 2026Article
- Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights FromAngewandte Chemie (International ed. in English) · 2025Article
- Identification of widely conserved biosynthetic gene cluster involved in pigment production ofmSystems · 2025Article
- Melanin in fungi: advances in structure, biosynthesis, regulation, and metabolic engineering.Microbial cell factories · 2024Review
- Bioproduction and optimization of newly characterized melanin pigment from Streptomyces djakartensis NSS-3 with its anticancer, antimicrobial, and radioprotective properties.Microbial cell factories · 2024Article
- Gut bacteria are essential for normal cuticle development in herbivorous turtle ants.Nature communications · 2021Article
- Tryptophan, a non-canonical melanin precursor: New L-tryptophan based melanin production by Rubrivivax benzoatilyticus JA2.Scientific reports · 2020Article
- The structural unit of melanin in the cell wall of the fungal pathogenThe Journal of biological chemistry · 2019Article
- Eumelanin Graphene-Like Integration: The Impact on Physical Properties and Electrical Conductivity.Frontiers in chemistry · 2019Article
- The melanization road more traveled by: Precursor substrate effects on melanin synthesis in cell-free and fungal cell systems.The Journal of biological chemistry · 2018Article
- Elucidation of the hierarchical structure of natural eumelanins.Journal of the Royal Society, Interface · 2018Article
- Article
- N-acetylglucosamine affects Cryptococcus neoformans cell-wall composition and melanin architecture.Microbiology (Reading, England) · 2017Article
- Functions of fungal melanin beyond virulence.Fungal biology reviews · 2017Article
- Melanin, Radiation, and Energy Transduction in Fungi.Microbiology spectrum · 2017Review
- Activation of Melanin Synthesis in Alternaria infectoria by Antifungal Drugs.Antimicrobial agents and chemotherapy · 2015Article
- Structural Characterization of Melanin Pigments from Commercial Preparations of the Edible Mushroom Auricularia auricula.Journal of agricultural and food chemistry · 2015Article
- Solid-state NMR Reveals the Carbon-based Molecular Architecture of Cryptococcus neoformans Fungal Eumelanins in the Cell Wall.The Journal of biological chemistry · 2015Article
- Fungal Melanin: What do We Know About Structure?Frontiers in microbiology · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Despite the essential functions of melanin pigments in diverse organisms and their roles in inspiring designed nanomaterials for electron transport and drug delivery, the structural frameworks of the natural materials and their biomimetic analogs remain poorly understood. To overcome the investigative challenges posed by these insoluble heterogeneous pigments, we have used l-tyrosine or dopamine enriched with stable (13)C and (15)N isotopes to label eumelanins metabolically in cell-free and Cryptococcus neoformans cell systems and to define their molecular structures and supramolecular architectures. Using high-field two-dimensional solid-state nuclear magnetic resonance (NMR), our study directly evaluates the assumption of structural commonality between synthetic melanin models and the corresponding natural pigments, demonstrating a common indole-based aromatic core in the products from contrasting synthetic protocols for the first time.
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